William C. Wimley  -   Department of Biochemistry, Tulane University Health Sciences Center

Recent Publications and Reprints

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Research Papers






Cynthia Paul, Jianping Wang, William C. Wimley, Robin M. Hochstrasser, and Paul H. Axelsen
(2004)  Vibrational Coupling, Isotopic Editing, and -Sheet Structure in a Membrane-Bound Polypeptide (2004)   J. Am. Chem. Soc.; 2004; 126(18) pp 5843 - 5850;
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Mohanty AK, Bishop CM, Bishop TC, Wimley WC, Wiener MC. (2003)  Enzymatic E-colicins bind to their target receptor BtuB by presentation of a small binding epitope on a coiled-coil scaffold.  J Biol Chem. 2003 Oct 17;278(42):40953-8.
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Wimley, WC; (2002) Toward Genomic Identification of beta-barrel Membrane Proteins: Composition and Architecture of Known Structures.Protein Sci. 11:301-12.
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Ashish; Wimley, WC; (2001) Visual Detection of Specific, Native Interactions Between Soluble And Microbead-tethered alpha-Helices from  Membrane Proteins. Biochemistry, 40:13753-9.
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Bishop CM; Walkenhorst WF; and Wimley WC; (2001) Folding of beta-sheets in membranes: Specificity and promiscuity in peptide model systems  Journal of Molecular Biology, 309(4):975-88.
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Rausch JM; Wimley WC; (2001)  A high-throughput screen for transmembrane pore-forming peptides.  Analytical Biochemistry, 293(2):258-63.
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Wimley WC; White, SH; (2000)  Designing transmembrane alpha-helices that insert spontaneously. Biochemistry, 39(15):4432-42. 
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Wimley, WC; White, SH  (2000) Determining the membrane topology of peptides by fluorescence quenching.   Biochemistry, 39(1):161-70. 
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Hristova K, Wimley WC, Mishra VK, Anantharamiah GM, Segrest JP, White SH.  (1999) An amphipathic  alpha-helix at a membrane interface: a structural study using a novel X-ray diffraction method  Journal of Molecular Biology, 90(1):99-117. 
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Yau, Y-M.; Wimley, WC; Gawrisch, K; White, SH (1998) The Preference of Tryptophan for Membrane Interfaces. Biochemistry, 37(42):14713-8. 
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Wimley,WC; Hristova, K., Silvestri, L., Axelsen, P.H., Ladokhin, AS; White, SH. (1998) Folding of  beta-sheet Membrane Proteins: A Hydrophobic Hexapeptide Model. Journal of Molecular Biology, 277:1091-1110.
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Wimley WC; White SH. (1996) Experimentally-Determined Interfacial Hydrophobicity Scale for Proteins in Membranes. Nature Structural Biology, 3, 842-848. 
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Wimley WC; Gawrisch K; Creamer TP; White SH. A  (1996) Direct Measurement of Salt-Bridge Solvation Energies Using A Peptide Model System: Implications for Protein Stability. Proceedings of the National Academy of Sciences,  93, 2985-2990.
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Samoszok MK; Wimley WC; and Nguyen V, (1996) Eradication of Interleukin 5-Transfected J558L Plasmocytomas in Mice by Hydrogen Peroxide Generating Stealth Liposomes. Cancer Research  56, 87-90. 
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Wimley WC; Creamer TP; White SH. (1996) Solvation Energies of Amino Acid Residues and Backbone in a Family of Host Guest Pentapeptides. Biochemistry,  35, 5109-5124
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Ladokhin AS; Wimley WC; White SH. (1995) Leakage of Membrane Vesicle Contents: Determination of Mechanism Using Fluorescence Requenching. Biophysical Journal  69:1964-1971
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Wimley, WC; Selsted ME; White SH. (1994) Interactions Between Human Defensins and Lipid Bilayers: Evidence for Formation of Multimeric Pores. Protein Science   3:1362-1373
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Wimley WC; White SH. (1993) Membrane Partitioning: Distinguishing Bilayer Effects from the Hydrophobic Effect. Biochemistry,  32:6307-12.
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Wimley WC; White SH. (1993) Quantitation of Electrostatic and Hydrophobic Membrane Interactions by Equilibrium Dialysis and Reverse Phase HPLC. Analytical Biochemistry, 213:213-217. 
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Wimley WC; White SH. (1992) Partitioning of Tryptophan Side-chain Analogs Between Water and Cyclohexane. Biochemistry,   31:12813-8.
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Review Papers




Wimley WC; (2003) The Versitile beta-Barrel Membrane Protein.  Current Opinion in Structural Biology. 13(4):401-411. 
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White SH; Wimley WC; (1999) Membrane Protein Folding and Stability:Physical Principles.  Annual Reviews of Biophysics and Biomolecular Structure 28:319-65 
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White, SH; Wimley WC (1998) Hydrophobic Interactions of Peptides with Membrane Interfaces Biochemica et Biophysica acta-reviews on biomembranes, 1376(3):339-352.
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Wimley, WC; Hristova, K; Ladokhin, AS; White, SH (1998) Protein Folding in Membranes: Determining the Energetics of Peptide-Bilayer Interactions.  Methods Enzymol., 295:62-87.
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Ladokhin AS; Wimley WC; Hristova, K; White SH. (1997) Mechanism of Leakage of Contents of Membrane Vesicles Determined by Fluorescence Requenching. Methods in Enzymology 278:474-86
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White SH; Wimley WC; Selsted ME. (1995) Structure, Function and Membrane Integration of Defensins. Current Opinion in Structural Biology.  5:521-527. 
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White SH; Wimley WC. (1994) Peptides in Lipid Bilayers - Structural and Thermodynamic Basis for Partitioning and Folding Current Opinion in Structural Biology  4:79-86.

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