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The Wimley Laboratory
Publications
Research Papers
Rathinakumar R, Walkenhorst WF, Wimley WC. (2009) Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity. J Am Chem Soc. 2009 Jun 10;131(22):7609-17. |
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Walkenhorst WF, Merzlyakov M, Hristova K, Wimley WC. (2009) Polar residues in transmembrane helices can decrease electrophoretic mobility in polyacrylamide gels without causing helix dimerization. Biochim Biophys Acta. 2009
Jun;1788(6):1321-31. |
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Chang WK, Wimley WC, Searson PC, Hristova K, Merzlyakov M. (2008) Characterization of antimicrobial peptide activity by electrochemical impedance spectroscopy. Biochim Biophys Acta. 2008 Oct;1778(10):2430-6. |
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Rathinakumar R, Wimley WC. (2008) Biomolecular engineering by combinatorial design and high-throughput screening: small, soluble peptides that permeabilize membranes. J Am Chem Soc. 2008 Jul 30;130(30):9849-58. |
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Han X, Hristova K, Wimley WC. (2008) Protein folding in membranes: insights from neutron diffraction studies of a membrane beta-sheet oligomer. Biophys J. 2008 Jan 15;94(2):492-505. |
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Costin JM, Rausch JM, Garry RF, Wimley WC. (2007) Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein. Virol J. 2007 Nov 20;4:123. |
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Rausch JM, Marks JR, Rathinakumar R, Wimley WC. (2007) Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. Biochemistry. 2007 Oct 30;46(43):12124-39. |
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Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF. (2006) Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein. Virus Res. 2006 Sep;120(1-2):146-55. |
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Naresh A, Long W, Vidal GA, Wimley WC, Marrero L, Sartor CI, Tovey S, Cooke TG, Bartlett JM, Jones FE. (2006) The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells. Cancer Res. 2006 Jun 15;66(12):6412-20. |
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Rausch JM, Marks JR, Wimley WC. ( 2005) Rational combinatorial design of pore-forming beta-sheet peptides. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10511-5. |
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Sainz B Jr, Rausch JM, Gallaher WR, Garry RF, Wimley WC.(2005) Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike protein. J Virol. 2005 Jun;79(11):7195-206. |
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You M, Li E, Wimley WC, Hristova K. (2005) Forster resonance energy transfer in liposomes: measurements of transmembrane helix dimerization in the native bilayer environment. Anal Biochem. 2005 May 1;340(1):154-64. |
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Sainz B Jr, Rausch JM, Gallaher WR, Garry RF, Wimley WC. (2005) The aromatic domain of the coronavirus class I viral fusion protein induces membrane permeabilization: putative role during viral entry. Biochemistry. 2005 Jan 25;44(3):947-58. |
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Wimley WC, White SH. (2004) Reversible unfolding of beta-sheets in membranes: a calorimetric study. J Mol Biol. 2004 Sep 17;342(3):703-11.
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Cynthia Paul, Jianping Wang, William C. Wimley, Robin M. Hochstrasser, and Paul H. Axelsen (2004) Vibrational Coupling, Isotopic Editing, and B-Sheet Structure in a Membrane-Bound Polypeptide (2004) J. Am. Chem. Soc.; 2004; 126(18) pp 5843 - 5850;
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Mohanty AK, Bishop CM, Bishop TC, Wimley WC, Wiener MC. (2003) Enzymatic E-colicins bind to their target receptor BtuB by presentation of a small binding epitope on a coiled-coil scaffold. J Biol Chem. 2003 Oct 17;278(42):40953-8. |
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Wimley, WC; (2002) Toward Genomic Identification of beta-barrel Membrane Proteins: Composition and Architecture of Known Structures.Protein Sci. 11:301-12. |
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Ashish; Wimley, WC; (2001) Visual Detection of Specific, Native Interactions Between Soluble And Microbead-tethered alpha-Helices from Membrane Proteins. Biochemistry, 40:13753-9. |
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Bishop CM; Walkenhorst WF; and Wimley WC; (2001) Folding of beta-sheets in membranes: Specificity and promiscuity in peptide model systems Journal of Molecular Biology, 309(4):975-88. |
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Rausch JM; Wimley WC; (2001) A high-throughput screen for transmembrane pore-forming peptides. Analytical Biochemistry, 293(2):258-63. |
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Wimley WC; White, SH; (2000) Designing transmembrane alpha-helices that insert spontaneously. Biochemistry, 39(15):4432-42. |
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Wimley, WC; White, SH (2000) Determining the membrane topology of peptides by fluorescence quenching. Biochemistry, 39(1):161-70. |
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Hristova K, Wimley WC, Mishra VK, Anantharamiah GM, Segrest JP, White SH. (1999) An amphipathic alpha-helix at a membrane interface: a structural study using a novel X-ray diffraction method Journal of Molecular Biology, 90(1):99-117. |
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Yau, Y-M.; Wimley, WC; Gawrisch, K; White, SH (1998) The Preference of Tryptophan for Membrane Interfaces. Biochemistry, 37(42):14713-8. |
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Wimley,WC; Hristova, K., Silvestri, L., Axelsen, P.H., Ladokhin, AS; White, SH. (1998) Folding of beta-sheet Membrane Proteins: A Hydrophobic Hexapeptide Model. Journal of Molecular Biology, 277:1091-1110. |
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Wimley WC; White SH. (1996) Experimentally-Determined Interfacial Hydrophobicity Scale for Proteins in Membranes. Nature Structural Biology, 3, 842-848. |
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Wimley WC; Gawrisch K; Creamer TP; White SH. A (1996) Direct Measurement of Salt-Bridge Solvation Energies Using A Peptide Model System: Implications for Protein Stability. Proceedings of the National Academy of Sciences, 93, 2985-2990. |
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Samoszok MK; Wimley WC; and Nguyen V, (1996) Eradication of Interleukin 5-Transfected J558L Plasmocytomas in Mice by Hydrogen Peroxide Generating Stealth Liposomes. Cancer Research 56, 87-90. |
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Wimley WC; Creamer TP; White SH. (1996) Solvation Energies of Amino Acid Residues and Backbone in a Family of Host Guest Pentapeptides. Biochemistry, 35, 5109-5124 |
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Ladokhin AS; Wimley WC; White SH. (1995) Leakage of Membrane Vesicle Contents: Determination of Mechanism Using Fluorescence Requenching. Biophysical Journal 69:1964-1971 |
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Wimley, WC; Selsted ME; White SH. (1994) Interactions Between Human Defensins and Lipid Bilayers: Evidence for Formation of Multimeric Pores. Protein Science 3:1362-1373 |
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Wimley WC; White SH. (1993) Membrane Partitioning: Distinguishing Bilayer Effects from the Hydrophobic Effect. Biochemistry, 32:6307-12. |
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Wimley WC; White SH. (1993) Quantitation of Electrostatic and Hydrophobic Membrane Interactions by Equilibrium Dialysis and Reverse Phase HPLC. Analytical Biochemistry, 213:213-217. |
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Wimley WC; White SH. (1992) Partitioning of Tryptophan Side-chain Analogs Between Water and Cyclohexane. Biochemistry, 31:12813-8. |
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Wimley WC, Thompson TE. (1991) Phosphatidylethanolamine enhances the concentration-dependent exchange of phospholipids between bilayers. Biochemistry. 1991 Apr 30;30(17):4200-4.
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Wimley WC, Thompson TE.(1991) Transbilayer and interbilayer phospholipid exchange in dimyristoylphosphatidylcholine / dimyristoylphosphatidylethanolamine large unilamellar vesicles. Biochemistry. 1991 Feb 12;30(6):1702-9. |
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Almog S, Litman BJ, Wimley W, Cohen J, Wachtel EJ, Barenholz Y, Ben-Shaul A, Lichtenberg D.(1990) States of aggregation and phase transformations in mixtures of phosphatidylcholine and octyl glucoside. Biochemistry. 1990 May 15;29(19):4582-92. |
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Wimley WC, Thompson TE. (1990) Exchange and flip-flop of dimyristoylphosphatidylcholine in liquid-crystalline, gel, and two component, two-phase large unilamellar vesicles. Biochemistry. 1990 Feb 6;29(5):1296-303. Erratum in: Biochemistry 1990 May 15;29(19):4746. |
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Wimley WC; (2003) The Versitile beta-Barrel Membrane Protein. Current Opinion in Structural Biology. 13(4):401-411. |
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White SH; Wimley WC; (1999) Membrane Protein Folding and Stability:Physical Principles. Annual Reviews of Biophysics and Biomolecular Structure 28:319-65 |
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White, SH; Wimley WC (1998) Hydrophobic Interactions of Peptides with Membrane Interfaces Biochemica et Biophysica acta-reviews on biomembranes, 1376(3):339-352. |
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Wimley, WC; Hristova, K; Ladokhin, AS; White, SH (1998) Protein Folding in Membranes: Determining the Energetics of Peptide-Bilayer Interactions. Methods Enzymol., 295:62-87. |
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Ladokhin AS; Wimley WC; Hristova, K; White SH. (1997) Mechanism of Leakage of Contents of Membrane Vesicles Determined by Fluorescence Requenching. Methods in Enzymology 278:474-86 |
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White SH; Wimley WC; Selsted ME. (1995) Structure, Function and Membrane Integration of Defensins. Current Opinion in Structural Biology. 5:521-527. |
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White SH; Wimley WC. (1994) Peptides in Lipid Bilayers - Structural and Thermodynamic Basis for Partitioning and Folding Current Opinion in Structural Biology 4:79-86.
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