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The Wimley Laboratory
Publications
Research Papers
He L, Hoffmann AR, Serrano C, Hristova K, Wimley WC. (2011) High-Throughput Selection of Transmembrane Sequences That Enhance Receptor Tyrosine Kinase Activation. J Mol Biol. 2011 Jul 12. [Epub ahead of print] |
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Datta S, Hazari S, Chandra PK, Samara M, Poat B, Gunduz F, Wimley WC, Hauser H, Koster M, Lamaze C, Balart LA, Garry RF, Dash S. (2011) Mechanism of HCV's resistance to IFN-alpha in cell culture involves expression of functional IFN-alpha receptor 1.Virol J. 2011 Jul 14;8(1):351. [Epub ahead of print] |
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Marks JR, Placone J, Hristova K, Wimley WC. (2011) Spontaneous membrane-translocating peptides by orthogonal high-throughput screening. J Am Chem Soc. 2011 Jun 15;133(23):8995-9004. Epub 2011 May 19. |
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He L, Shobnam N, Wimley WC, Hristova K. (2011) FGFR3 heterodimerization in achondroplasia, the most common form of human dwarfism. J Biol Chem. 2011 Apr 15;286(15):13272-81. Epub 2011 Feb 15. |
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Wimley WC, Hristova K.(2011) Antimicrobial peptides: successes, challenges and unanswered questions. J Membr Biol. 2011 Jan;239(1-2):27-34. Epub 2011 Jan 12. Review. |
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Hristova K, Wimley WC. (2010) A look at arginine in membranes. J Membr Biol. 2011 Jan;239(1-2):49-56. Epub 2010 Nov 25. Review. |
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Freeman TC Jr, Landry SJ, Wimley WC. (2010) The prediction and characterization of YshA, an unknown outer-membrane protein from Salmonella typhimurium. Biochim Biophys Acta. 2011 Jan;1808(1):287-97. Epub 2010 Sep 20. |
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Wimley WC. (2010) Describing the mechanism of antimicrobial peptide action with the interfacial activity model. ACS Chem Biol. 2010 Oct 15;5(10):905-17. Review. |
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Wimley WC. (2010) Energetics of peptide and protein binding to lipid membranes.Adv Exp Med Biol. 2010;677:14-23. Review. |
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Gerlach SL, Rathinakumar R, Chakravarty G, Göransson U, Wimley WC, Darwin SP, Mondal D.(2010) Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa.Biopolymers. 2010;94(5):617-25. |
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Freeman TC Jr, Wimley WC.(2010) A highly accurate statistical approach for the prediction of transmembrane beta-barrels.Bioinformatics. 2010 Aug 15;26(16):1965-74. Epub 2010 Jun 10. |
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Rathinakumar R, Wimley WC. (2010)
High-throughput discovery of broad-spectrum peptide antibiotics.
FASEB J. 2010 Sep;24(9):3232-8. Epub 2010 Apr 21.
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Rathinakumar R, Walkenhorst WF, Wimley WC. (2009) Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity. J Am Chem Soc. 2009 Jun 10;131(22):7609-17. |
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Walkenhorst WF, Merzlyakov M, Hristova K, Wimley WC. (2009) Polar residues in transmembrane helices can decrease electrophoretic mobility in polyacrylamide gels without causing helix dimerization. Biochim Biophys Acta. 2009
Jun;1788(6):1321-31. |
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Chang WK, Wimley WC, Searson PC, Hristova K, Merzlyakov M. (2008) Characterization of antimicrobial peptide activity by electrochemical impedance spectroscopy. Biochim Biophys Acta. 2008 Oct;1778(10):2430-6. |
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Rathinakumar R, Wimley WC. (2008) Biomolecular engineering by combinatorial design and high-throughput screening: small, soluble peptides that permeabilize membranes. J Am Chem Soc. 2008 Jul 30;130(30):9849-58. |
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Han X, Hristova K, Wimley WC. (2008) Protein folding in membranes: insights from neutron diffraction studies of a membrane beta-sheet oligomer. Biophys J. 2008 Jan 15;94(2):492-505. |
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Costin JM, Rausch JM, Garry RF, Wimley WC. (2007) Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein. Virol J. 2007 Nov 20;4:123. |
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Rausch JM, Marks JR, Rathinakumar R, Wimley WC. (2007) Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. Biochemistry. 2007 Oct 30;46(43):12124-39. |
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Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF. (2006) Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein. Virus Res. 2006 Sep;120(1-2):146-55. |
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Naresh A, Long W, Vidal GA, Wimley WC, Marrero L, Sartor CI, Tovey S, Cooke TG, Bartlett JM, Jones FE. (2006) The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells. Cancer Res. 2006 Jun 15;66(12):6412-20. |
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Rausch JM, Marks JR, Wimley WC. ( 2005) Rational combinatorial design of pore-forming beta-sheet peptides. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10511-5. |
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Sainz B Jr, Rausch JM, Gallaher WR, Garry RF, Wimley WC.(2005) Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike protein. J Virol. 2005 Jun;79(11):7195-206. |
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You M, Li E, Wimley WC, Hristova K. (2005) Forster resonance energy transfer in liposomes: measurements of transmembrane helix dimerization in the native bilayer environment. Anal Biochem. 2005 May 1;340(1):154-64. |
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Sainz B Jr, Rausch JM, Gallaher WR, Garry RF, Wimley WC. (2005) The aromatic domain of the coronavirus class I viral fusion protein induces membrane permeabilization: putative role during viral entry. Biochemistry. 2005 Jan 25;44(3):947-58. |
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Wimley WC, White SH. (2004) Reversible unfolding of beta-sheets in membranes: a calorimetric study. J Mol Biol. 2004 Sep 17;342(3):703-11. |
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Cynthia Paul, Jianping Wang, William C. Wimley, Robin M. Hochstrasser, and Paul H. Axelsen (2004) Vibrational Coupling, Isotopic Editing, and B-Sheet Structure in a Membrane-Bound Polypeptide (2004) J. Am. Chem. Soc.; 2004; 126(18) pp 5843 - 5850;
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Wimley WC; (2003) The Versitile beta-Barrel Membrane Protein. Current Opinion in Structural Biology. 13(4):401-411. |
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Mohanty AK, Bishop CM, Bishop TC, Wimley WC, Wiener MC. (2003) Enzymatic E-colicins bind to their target receptor BtuB by presentation of a small binding epitope on a coiled-coil scaffold. J Biol Chem. 2003 Oct 17;278(42):40953-8. |
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Wimley, WC; (2002) Toward Genomic Identification of beta-barrel Membrane Proteins: Composition and Architecture of Known Structures.Protein Sci. 11:301-12. |
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Ashish; Wimley, WC; (2001) Visual Detection of Specific, Native Interactions Between Soluble And Microbead-tethered alpha-Helices from Membrane Proteins. Biochemistry, 40:13753-9. |
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Bishop CM; Walkenhorst WF; and Wimley WC; (2001) Folding of beta-sheets in membranes: Specificity and promiscuity in peptide model systems Journal of Molecular Biology, 309(4):975-88. |
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Rausch JM; Wimley WC; (2001) A high-throughput screen for transmembrane pore-forming peptides. Analytical Biochemistry, 293(2):258-63. |
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Wimley WC; White, SH; (2000) Designing transmembrane alpha-helices that insert spontaneously. Biochemistry, 39(15):4432-42. |
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Wimley, WC; White, SH (2000) Determining the membrane topology of peptides by fluorescence quenching. Biochemistry, 39(1):161-70. |
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Hristova K, Wimley WC, Mishra VK, Anantharamiah GM, Segrest JP, White SH. (1999) An amphipathic alpha-helix at a membrane interface: a structural study using a novel X-ray diffraction method Journal of Molecular Biology, 90(1):99-117. |
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White SH; Wimley WC; (1999) Membrane Protein Folding and Stability:Physical Principles. Annual Reviews of Biophysics and Biomolecular Structure 28:319-65 |
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Yau, Y-M.; Wimley, WC; Gawrisch, K; White, SH (1998) The Preference of Tryptophan for Membrane Interfaces. Biochemistry, 37(42):14713-8. |
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White, SH; Wimley WC (1998) Hydrophobic Interactions of Peptides with Membrane Interfaces Biochemica et Biophysica acta-reviews on biomembranes, 1376(3):339-352. |
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Wimley, WC; Hristova, K; Ladokhin, AS; White, SH (1998) Protein Folding in Membranes: Determining the Energetics of Peptide-Bilayer Interactions. Methods Enzymol., 295:62-87. |
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Wimley,WC; Hristova, K., Silvestri, L., Axelsen, P.H., Ladokhin, AS; White, SH. (1998) Folding of beta-sheet Membrane Proteins: A Hydrophobic Hexapeptide Model. Journal of Molecular Biology, 277:1091-1110. |
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Ladokhin AS; Wimley WC; Hristova, K; White SH. (1997) Mechanism of Leakage of Contents of Membrane Vesicles Determined by Fluorescence Requenching. Methods in Enzymology 278:474-86 |
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Wimley WC; White SH. (1996) Experimentally-Determined Interfacial Hydrophobicity Scale for Proteins in Membranes. Nature Structural Biology, 3, 842-848. |
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Wimley WC; Gawrisch K; Creamer TP; White SH. A (1996) Direct Measurement of Salt-Bridge Solvation Energies Using A Peptide Model System: Implications for Protein Stability. Proceedings of the National Academy of Sciences, 93, 2985-2990. |
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Samoszok MK; Wimley WC; and Nguyen V, (1996) Eradication of Interleukin 5-Transfected J558L Plasmocytomas in Mice by Hydrogen Peroxide Generating Stealth Liposomes. Cancer Research 56, 87-90. |
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Wimley WC; Creamer TP; White SH. (1996) Solvation Energies of Amino Acid Residues and Backbone in a Family of Host Guest Pentapeptides. Biochemistry, 35, 5109-5124 |
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White SH; Wimley WC; Selsted ME. (1995) Structure, Function and Membrane Integration of Defensins. Current Opinion in Structural Biology. 5:521-527. |
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Ladokhin AS; Wimley WC; White SH. (1995) Leakage of Membrane Vesicle Contents: Determination of Mechanism Using Fluorescence Requenching. Biophysical Journal 69:1964-1971 |
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White SH; Wimley WC. (1994) Peptides in Lipid Bilayers - Structural and Thermodynamic Basis for Partitioning and Folding Current Opinion in Structural Biology 4:79-86.
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Wimley, WC; Selsted ME; White SH. (1994) Interactions Between Human Defensins and Lipid Bilayers: Evidence for Formation of Multimeric Pores. Protein Science 3:1362-1373 |
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Wimley WC; White SH. (1993) Membrane Partitioning: Distinguishing Bilayer Effects from the Hydrophobic Effect. Biochemistry, 32:6307-12. |
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Wimley WC; White SH. (1993) Quantitation of Electrostatic and Hydrophobic Membrane Interactions by Equilibrium Dialysis and Reverse Phase HPLC. Analytical Biochemistry, 213:213-217. |
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Wimley WC; White SH. (1992) Partitioning of Tryptophan Side-chain Analogs Between Water and Cyclohexane. Biochemistry, 31:12813-8. |
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Wimley WC, Thompson TE.(1991) Transbilayer and interbilayer phospholipid exchange in dimyristoylphosphatidylcholine / dimyristoylphosphatidylethanolamine large unilamellar vesicles. Biochemistry. 1991 Feb 12;30(6):1702-9. |
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Almog S, Litman BJ, Wimley W, Cohen J, Wachtel EJ, Barenholz Y, Ben-Shaul A, Lichtenberg D.(1990) States of aggregation and phase transformations in mixtures of phosphatidylcholine and octyl glucoside. Biochemistry. 1990 May 15;29(19):4582-92. |
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Wimley WC, Thompson TE. (1990) Exchange and flip-flop of dimyristoylphosphatidylcholine in liquid-crystalline, gel, and two component, two-phase large unilamellar vesicles. Biochemistry. 1990 Feb 6;29(5):1296-303. Erratum in: Biochemistry 1990 May 15;29(19):4746. |
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