Interesting Membrane Proteins



 
Three Dimensional Structure of  a Toxin: a-hemolysin from Staphylococcus aureus 
 

Ribbon diagram of the a-toxin of S. aureus. Reference.  The b-barrel stalk of this mushroom-shaped protein inserts across succepible membranes and caused lethal permeability changes in the membrane by virtue of  the toxins central pore. 

This molecule is a homo-heptamer, composed of 7 identical subunits. It is probably a member of a widespread class of similar toxin molecules, including aerolysin, leukocidin, the Anthrax protective antigen and others.

 
Top view of the same molecule.  Notice the pore through the middle of the structure. 
 
 
 
PDB acess code 2AHL 
 

Get PDB file for this molecule 
 
 

 


 
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