GBCH 718
"Molecular Biology of Gene Structure and Function"
Tuesday and Thursday
1:00-3:00 p.m.
Room 6301 Medical School
COURSE DIRECTOR:  ARTHUR LUSTIG, Ph.D.
 

    This course will combine didactic training with more problem-based learning (i.e. working through real research problems) and discussions of primary manuscripts.

    PBL refers to problem sets designed to teach students how to draw hypotheses from experimental data and design testable models.

There are two major goals of this course:
                 1.    Teach students material and approaches not covered in other course.
                 2.    Teach students how to think about experimental problems and evaluate the  literature.

 

TEXTBOOK:   Griffiths, J. F., Miller, J. H. and Suzuki, D. T.  An Introductory to Genetic Analysis, 6th Edition, Publisher W. H. Freeman & Co
 
 
Schedule
 
PART I
MOLECULAR GENETICS AND GENETICS FOUNDATION

 
DATE
TITLE
TYPE
INSTRUCTOR
January 14, 1999 Course Introduction Dr. Lustig
January 19, 1999 Mendelian Inheritance  
Chapters 1, 2, 4		 Lecture Dr. Hemenway
January 21, 1999 Interpretation of Genetic Data PBL Holly Wyatt
January 26, 1999 Complementation/Allelism  
Chapter 12		 Lecture Dr. Hemenway
January 28, 1999 Complementation/Allelism  PBL Holly Wyatt
February 2, 1999 Recombinational Mapping  
Chapters 5,6		 Lecture Dr. Hemenway
February 4, 1999 Recombinational Mapping PBL Holly Wyatt
February 9, 
1999		 Suppression Analysis  Lecture Dr. 
Hemenway
February 11, 1999 Paper Discussion on Suppression Analysis Paper Discussion Dr. Lustig
February 16, 1999 Mardi Gras Holiday
February 18, 1999 EXAM
 
PART II
CHROMOSOME DYNAMICS
 
DATE
TITLE
TYPE
INSTRUCTOR
February 23, 1999 Molecular Dissection and Construction of the Chromosome 
Chapters 8,9		 Lecture Dr. Miller
February 25, 1999 DNA Replication in Prokaryotes-Integration of Genetics and Biochemistry  
Chapter 11		 Lecture Dr. Miller
March 2, 1999 Problem Set on Chromosome Structure and Replication  PBL TBA
March 4, 1999 DNA Replication in Eukaryotes-Integration of Genetics and Biochemistry  
Chapter 16		 Lecture Dr. Miller
March 9, 1999 Dissection of Orc/Pre-Postreplicative Complexes Paper Discussion TBA
March 11, 1999 Recombination - Basic Principles 
Chapter 10		 Lecture Dr. Lustig
March 16 1999 Recombination PBL TBA
March 18, 1999 Recombination -Towards a Model for Recombination 
Chapter 20		 Lecture Dr. Lustig
March 23, 1999 Recombination in Eukaryotes PBL TBA
March 25, 1999 Recombination in Other Systems Paper Discussion TBA
March 28-April 4, 1999 SPRING BREAK
April 6, 1999 EXAM
 
PART III
MOLECULAR GENETIC APPROACHES TOWARDS
HIGHER LEVEL REGULATION OF TRANSCRIPTION
 
DATE
TITLE
TYPE
INSTRUCTOR
April 13, 1999 Review of Basal Transcription in Eukaryotes 
Chapter 23		 Lecture Dr. Morris
April 15, 1999 Regulatory Circuits in Eukaryotes Transcriptional Regulation  I- Mating Type Locus  
Chapter 25		 Lecture Dr. Lustig
April 20, 1999 Regulatory Circuits in Eukaryotes Transcriptional Regulation II - Mating Type Locus  
Chapter 25		 Lecture Dr. Lustig
April 22, 1999 Regulatory Circuits in ETR-Signal Transduction Lecture Dr. Clancy
April 27, 1999 Regulatory Circuits PBL TBA
April 29, 1999 Regulatory Circuits in 
ETR-Chromatin Remodeling 
Machinery		 Lecture Dr. Lustig
May 4, 1999 Integration View of Regulation-From Post-Translational Modification to Chromatin Structure  Paper Discussion Yangsuk Park
 
 
PAPER DUE AT END OF EXAM WEEK
 
 
 

For more information, contact Arthur Lustig, Ph.D. at:     alustig@mailhost.tcs.tulane.edu