@text

 Tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitor SU4984 by Lixin Qi

Protein tyrosine kinase (PTKs) are essential in signal transduction pathways that control cell proliferation and differentiation. Enhanced PTK activity has been implicated in many human cancers. So selective inhibitors of PTK may have therapeutic value.

Fibroblast growth factors (FGF) play important roles in embryonic development, angiogenesis, wound healing and malignant transformation and their function is mediated by four transmembrane receptors (FGFR1 through FGFR4) with intrinsic PTK activity. FGFR1K (FGFR1 Tyrosine Kinase Domain) has a two-lobe architecture typical of protein kinases. ATP binds to FGFR1K in the cleft between the two lobes.

SU4984, 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone is a compound that can inhibit the function of FGFR1. SU4984 binds to the same region as ATP. The oxindole of the inhibitor occupies the same site as the ATP adenine. The oxindole makes two hydrogen bonds to the backbone of FGFR1K. They are N-1 to the carbonyl oxygen of Glu562 and O-2 to the amide nitrogen of Ala564. The hydrophobic residues including: Val492, Ala512, Ile545, Val561, Ala564 and Leu630 are in the cavity to which oxindole binds. Also residues Leu484 and Tyr563 provide a hydrophobic environment for the phenyl ring of the SU4984.

Reference: Mohammadi, M., McMahon, G., Sun, L., Tang, C., Hirth,P., Yeh, B. K., Hubbard, S. R., Schlessinger, J.: Structure of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitor. Science 276 pp. 955 (1997)

@kinemage 1
@caption
Fibroblast Growth Factor Receptor 1 in complex with SU4984 from the side view.
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{ ca  gly b 485  B52.06}64.036 8.317 3.414
{ ca  glu b 486  B56.67}63.881 12.101 3.733
{ ca  gly b 487  B58.95}62.123 14.951 5.491
{ ca  ala b 488  B61.28}62.447 18.650 6.265
{ ca  phe b 489  B61.83}66.150 19.472 5.823
{ ca  gly b 490  B55.79}67.132 15.884 6.665
{ ca  gln b 491  B50.09}67.890 12.790 4.587
{ ca  val b 492  B41.47}68.594 9.113 5.340
{ ca  val b 493  B38.19}70.499 6.939 2.898
{ ca  leu b 494  B40.64}71.486 3.286 2.884
{ ca  ala b 495  B42.24}75.230 2.777 2.921
{ ca  glu b 496  B45.19}77.923 0.136 3.286
{ ca  ala b 497  B43.48}80.430 0.764 6.036
{ ca  ile b 498  B47.96}83.736 -1.106 6.274
{ ca  gly b 499  B54.30}85.406 -2.052 9.547
{ ca  leu b 500  B58.78}82.948 -0.239 11.827
{ ca  pro b 505  B79.94}P 87.900 -4.745 10.173
{"}87.900 -4.745 10.173
{ ca  asn b 506  B74.27}87.534 -5.451 6.455
{ ca  arg b 507  B68.37}83.971 -6.786 6.383
{ ca  val b 508  B60.01}81.268 -4.479 5.071
{ ca  thr b 509  B50.99}78.188 -3.643 7.131
{ ca  lys b 510  B46.14}75.031 -2.321 5.469
{ ca  val b 511  B35.88}73.989 0.746 7.539
{ ca  ala b 512  B28.54}71.756 3.839 7.512
{ ca  val b 513  B27.06}73.311 7.317 7.338
{ ca  lys b 514  B27.37}71.406 10.405 8.492
{ ca  met b 515  B28.93}72.648 13.727 7.091
{ ca  leu b 516  B30.43}71.462 17.219 6.180
{ ca  lys b 517  B34.53}69.853 18.303 2.916
{ ca  ser b 518  B34.06}71.528 20.986 0.751
{ ca  asp b 519  B37.74}68.874 23.478 1.904
{ ca  ala b 520  B35.45}69.636 22.999 5.608
{ ca  thr b 521  B36.03}70.571 25.837 7.952
{ ca  glu b 522  B41.67}73.000 25.843 10.871
{ ca  lys b 523  B34.58}70.045 25.359 13.216
{ ca  asp b 524  B28.67}69.343 22.149 11.303
{ ca  leu b 525  B27.30}73.011 21.184 11.694
{ ca  ser b 526  B30.64}72.728 21.886 15.424
{ ca  asp b 527  B29.62}69.709 19.592 15.595
{ ca  leu b 528  B30.02}71.560 16.730 13.867
{ ca  ile b 529  B28.64}74.595 17.131 16.162
{ ca  ser b 530  B33.86}72.413 17.211 19.284
{ ca  glu b 531  B28.16}70.732 13.984 18.190
{ ca  met b 532  B28.37}74.052 12.141 17.662
{ ca  glu b 533  B27.94}75.226 13.349 21.068
{ ca  met b 534  B30.84}71.995 12.209 22.731
{ ca  met b 535  B30.47}72.476 8.732 21.223
{ ca  lys b 536  B34.35}75.988 8.785 22.669
{ ca  met b 537  B35.74}74.626 9.623 26.142
{ ca  ile b 538  B29.57}71.837 7.014 26.011
{ ca  gly b 539  B29.00}73.980 3.976 25.188
{ ca  lys b 540  B31.31}73.219 0.718 23.359
{ ca  his b 541  B32.10}70.211 -1.614 23.467
{ ca  lys b 542  B31.07}68.922 -4.425 21.210
{ ca  asn b 543  B26.67}65.518 -2.827 20.831
{ ca  ile b 544  B27.78}66.603 0.692 19.786
{ ca  ile b 545  B26.58}68.378 2.074 16.699
{ ca  asn b 546  B26.23}72.017 2.336 17.792
{ ca  leu b 547  B28.84}74.851 4.755 16.938
{ ca  leu b 548  B30.12}77.592 2.969 14.957
{ ca  gly b 549  B32.39}79.809 5.868 13.909
{ ca  ala b 550  B29.92}80.141 9.354 12.464
{ ca  cys b 551  B25.77}81.981 11.370 9.810
{ ca  thr b 552  B25.57}82.120 14.846 11.374
{ ca  gln b 553  B26.89}85.392 16.181 9.955
{ ca  asp b 554  B28.95}86.144 17.635 6.522
{ ca  gly b 555  B28.68}82.746 17.474 4.848
{ ca  pro b 556  B26.14}79.014 17.029 5.648
{ ca  leu b 557  B30.09}78.137 15.388 8.954
{ ca  tyr b 558  B26.02}77.139 11.738 8.674
{ ca  val b 559  B25.83}75.402 10.017 11.605
{ ca  ile b 560  B26.86}75.798 6.292 10.989
{ ca  val b 561  B28.33}73.125 4.125 12.577
{ ca  glu b 562  B29.06}71.701 0.573 12.303
{ ca  tyr b 563  B34.43}69.797 -0.475 9.169
{ ca  ala b 564  B39.80}66.288 -1.981 9.360
{ ca  ser b 565  B39.76}65.724 -3.997 6.181
{ ca  lys b 566  B39.90}62.000 -4.437 6.778
{ ca  gly b 567  B38.71}61.022 -0.798 7.238
{ ca  asn b 568  B38.61}58.677 0.424 9.946
{ ca  leu b 569  B38.01}56.301 -1.703 11.995
{ ca  arg b 570  B39.32}53.113 -0.309 10.442
{ ca  glu b 571  B41.59}54.196 -1.473 7.011
{ ca  tyr b 572  B38.46}55.686 -4.726 8.370
{ ca  leu b 573  B38.00}52.299 -5.583 9.894
{ ca  gln b 574  B42.46}50.159 -4.721 6.874
{ ca  ala b 575  B40.45}52.357 -6.758 4.527
{ ca  arg b 576  B45.29}51.663 -9.818 6.681
{ ca  arg b 577  B52.97}47.923 -9.626 7.318
{ ca  gln b 594  B66.99}P 52.156 -14.134 8.604
{"}52.156 -14.134 8.604
{ ca  leu b 595  B59.03}52.523 -13.508 12.326
{ ca  ser b 596  B50.46}51.133 -15.656 15.149
{ ca  ser b 597  B52.62}49.489 -14.360 18.320
{ ca  lys b 598  B53.07}52.821 -14.995 20.043
{ ca  asp b 599  B48.60}54.622 -13.042 17.294
{ ca  leu b 600  B41.55}52.311 -10.062 17.875
{ ca  val b 601  B42.86}52.870 -10.262 21.650
{ ca  ser b 602  B39.96}56.596 -10.701 21.028
{ ca  cys b 603  B36.08}56.692 -7.465 18.987
{ ca  ala b 604  B36.74}54.927 -5.646 21.858
{ ca  tyr b 605  B36.93}57.272 -7.072 24.505
{ ca  gln b 606  B33.49}60.316 -6.035 22.413
{ ca  val b 607  B31.67}58.895 -2.501 21.976
{ ca  ala b 608  B29.79}58.230 -2.082 25.711
{ ca  arg b 609  B33.10}61.814 -3.145 26.433
{ ca  gly b 610  B27.39}63.461 -0.561 24.187
{ ca  met b 611  B27.43}61.236 2.004 25.823
{ ca  glu b 612  B34.41}62.059 0.701 29.314
{ ca  tyr b 613  B34.50}65.708 1.178 28.355
{ ca  leu b 614  B32.81}65.236 4.702 26.969
{ ca  ala b 615  B39.94}63.139 5.545 30.024
{ ca  ser b 616  B41.80}65.885 4.274 32.344
{ ca  lys b 617  B37.99}68.048 6.732 30.404
{ ca  lys b 618  B36.69}65.573 9.541 31.131
{ ca  cys b 619  B33.41}64.641 9.682 27.440
{ ca  ile b 620  B30.12}61.126 10.801 26.490
{ ca  his b 621  B31.90}60.373 9.894 22.871
{ ca  arg b 622  B36.98}57.324 12.205 22.612
{ ca  asp b 623  B34.41}56.198 10.366 19.444
{ ca  leu b 624  B31.20}56.220 6.617 20.010
{ ca  ala b 625  B25.54}54.197 5.003 17.201
{ ca  ala b 626  B27.27}54.476 1.955 14.912
{ ca  arg b 627  B27.44}55.781 4.316 12.230
{ ca  asn b 628  B27.51}58.746 5.081 14.541
{ ca  val b 629  B26.97}59.618 1.447 15.191
{ ca  leu b 630  B29.29}61.867 -0.260 12.647
{ ca  val b 631  B32.37}62.207 -4.010 11.994
{ ca  thr b 632  B38.10}65.531 -5.696 11.163
{ ca  glu b 633  B44.59}66.214 -8.600 8.778
{ ca  asp b 634  B43.65}66.142 -10.866 11.821
{ ca  asn b 635  B39.28}62.748 -9.454 12.831
{ ca  val b 636  B34.89}64.041 -7.414 15.781
{ ca  met b 637  B30.38}61.958 -4.435 16.921
{ ca  lys b 638  B25.89}63.974 -1.208 17.320
{ ca  ile b 639  B24.90}62.806 2.213 18.563
{ ca  ala b 640  B28.33}63.856 4.966 16.148
{ ca  asp b 641  B32.45}63.952 8.792 16.464
{ ca  phe b 642  B30.28}64.149 8.783 20.273
{ ca  gly b 643  B34.26}66.903 11.404 20.090
{ ca  leu b 644  B43.72}65.283 13.963 17.756
{ ca  ala b 645  B51.79}65.266 17.613 18.837
{ ca  asp b 652  B80.42}P 51.324 22.053 14.279
{"}51.324 22.053 14.279
{ ca  tyr b 653  B82.65}48.516 19.789 15.480
{ ca  tyr b 654  B81.11}47.126 19.909 11.949
{ ca  lys b 655  B82.27}50.162 18.441 10.179
{ ca  lys b 656  B81.61}49.517 14.949 8.805
{ ca  gly b 660  B53.51}P 48.046 10.918 5.997
{"}48.046 10.918 5.997
{ ca  arg b 661  B48.14}47.422 10.208 9.681
{ ca  leu b 662  B38.64}47.458 12.822 12.445
{ ca  pro b 663  B38.08}50.200 12.221 15.056
{ ca  val b 664  B33.03}48.044 14.019 17.639
{ ca  lys b 665  B28.80}46.189 10.693 17.711
{ ca  trp b 666  B30.28}49.037 9.052 19.662
{ ca  met b 667  B38.02}49.366 11.942 22.121
{ ca  ala b 668  B39.11}48.345 11.585 25.747
{ ca  pro b 669  B40.07}45.769 14.157 26.976
{ ca  glu b 670  B42.64}48.150 16.111 29.234
{ ca  ala b 671  B44.95}50.739 16.473 26.447
{ ca  leu b 672  B53.73}48.129 17.696 23.959
{ ca  phe b 673  B56.50}46.327 19.955 26.452
{ ca  asp b 674  B60.56}48.833 20.768 29.232
{ ca  arg b 675  B56.51}52.026 20.346 27.128
{ ca  ile b 676  B55.01}53.205 17.961 29.854
{ ca  tyr b 677  B55.09}55.523 15.412 28.272
{ ca  thr b 678  B45.00}56.524 12.607 30.634
{ ca  his b 679  B38.64}57.569 8.959 30.499
{ ca  gln b 680  B39.05}53.901 8.290 31.288
{ ca  ser b 681  B37.04}52.646 10.214 28.254
{ ca  asp b 682  B32.51}54.940 7.857 26.311
{ ca  val b 683  B30.79}53.097 5.008 28.040
{ ca  trp b 684  B31.40}49.829 6.368 26.539
{ ca  ser b 685  B26.19}51.363 6.421 23.044
{ ca  phe b 686  B28.51}52.477 2.819 23.657
{ ca  gly b 687  B32.27}48.818 1.841 24.192
{ ca  val b 688  B29.44}47.895 3.175 20.771
{ ca  leu b 689  B30.49}50.952 1.333 19.397
{ ca  leu b 690  B32.60}49.600 -1.906 20.937
{ ca  trp b 691  B32.13}46.264 -1.212 19.266
{ ca  glu b 692  B31.13}48.190 -0.765 15.996
{ ca  ile b 693  B33.13}49.754 -4.175 16.502
{ ca  phe b 694  B36.54}46.544 -6.066 17.153
{ ca  thr b 695  B32.05}44.841 -4.488 14.134
{ ca  leu b 696  B29.65}47.934 -5.267 12.043
{ ca  gly b 697  B32.42}48.746 -1.711 10.925
{ ca  gly b 698  B32.31}45.417 -0.102 11.693
{ ca  ser b 699  B30.75}44.685 3.597 11.354
{ ca  pro b 700  B32.37}43.381 5.043 14.641
{ ca  tyr b 701  B31.67}40.359 7.347 14.349
{ ca  pro b 702  B28.06}39.959 7.132 10.569
{ ca  gly b 703  B25.38}38.173 10.208 9.279
{ ca  val b 704  B30.65}38.522 12.137 12.568
{ ca  pro b 705  B31.11}39.958 15.662 12.206
{ ca  val b 706  B38.48}41.966 17.420 14.931
{ ca  glu b 707  B41.20}39.037 19.373 16.379
{ ca  glu b 708  B40.93}36.888 16.251 16.653
{ ca  leu b 709  B39.74}39.660 14.266 18.349
{ ca  phe b 710  B43.15}39.929 17.002 20.969
{ ca  lys b 711  B44.12}36.218 16.620 21.618
{ ca  leu b 712  B43.97}36.469 12.812 21.705
{ ca  leu b 713  B46.71}39.299 12.970 24.242
{ ca  lys b 714  B44.59}37.370 15.405 26.474
{ ca  glu b 715  B41.25}34.475 12.913 26.517
{ ca  gly b 716  B41.06}36.791 10.178 27.780
{ ca  his b 717  B44.66}36.346 8.286 24.508
{ ca  arg b 718  B46.77}38.504 5.181 24.141
{ ca  met b 719  B48.95}38.918 2.988 21.040
{ ca  asp b 720  B53.28}37.046 -0.327 20.772
{ ca  lys b 721  B49.81}38.788 -3.587 21.543
{ ca  pro b 722  B46.94}40.146 -5.026 18.284
{ ca  ser b 723  B44.50}39.077 -8.439 17.039
{ ca  asn b 724  B51.03}41.822 -10.993 17.715
{ ca  cys b 725  B50.90}42.793 -9.401 20.996
{ ca  thr b 726  B51.84}42.331 -10.882 24.448
{ ca  asn b 727  B53.98}40.405 -8.952 27.087
{ ca  glu b 728  B51.11}43.750 -8.959 28.906
{ ca  leu b 729  B42.56}45.678 -7.214 26.128
{ ca  tyr b 730  B41.88}42.821 -4.770 25.723
{ ca  met b 731  B47.50}42.800 -3.817 29.388
{ ca  met b 732  B41.48}46.543 -3.273 29.022
{ ca  met b 733  B39.54}45.690 -0.738 26.284
{ ca  arg b 734  B42.38}42.987 0.736 28.526
{ ca  asp b 735  B42.12}45.596 0.926 31.292
{ ca  cys b 736  B36.19}47.968 2.945 29.129
{ ca  trp b 737  B44.37}44.977 5.139 28.302
{ ca  his b 738  B47.14}44.105 6.090 31.894
{ ca  ala b 739  B49.46}43.326 9.814 32.306
{ ca  val b 740  B50.52}45.559 10.194 35.389
{ ca  pro b 741  B48.76}49.224 9.573 34.340
{ ca  ser b 742  B52.67}50.232 8.188 37.751
{ ca  gln b 743  B50.00}47.733 5.383 37.247
{ ca  arg b 744  B43.04}48.990 4.213 33.856
{ ca  pro b 745  B41.05}51.442 1.319 34.125
{ ca  thr b 746  B37.25}55.167 2.012 33.846
{ ca  phe b 747  B36.87}57.341 0.492 31.107
{ ca  lys b 748  B43.44}58.973 -1.688 33.751
{ ca  gln b 749  B43.11}55.531 -3.174 34.530
{ ca  leu b 750  B37.71}54.492 -3.547 30.885
{ ca  val b 751  B39.40}57.739 -5.393 30.218
{ ca  glu b 752  B46.49}56.875 -7.712 33.119
{ ca  asp b 753  B47.29}53.249 -8.323 32.067
{ ca  leu b 754  B46.92}54.174 -8.729 28.416
{ ca  asp b 755  B50.86}56.947 -11.148 29.341
{ ca  arg b 756  B52.10}54.383 -13.261 31.201
{ ca  ile b 757  B45.22}51.672 -12.980 28.527
{ ca  val b 758  B46.86}54.128 -13.923 25.741
{ ca  ala b 759  B54.85}54.757 -17.173 27.629
{ ca  leu b 760  B57.71}51.078 -17.921 28.181
{ ca  thr b 761  B61.59}50.443 -17.417 24.440
@group {1AGW} dominant
@subgroup {het groups}
@vectorlist {het} color= pink master= {hets}
{ n1  su2   1000  B41.46}P 67.514 2.841 10.212
{"}67.514 2.841 10.212
{ c2  su2   1000  B43.16}66.851 2.673 9.024
{ o2  su2   1000  B39.20}67.030 1.653 8.348
{ c2  su2   1000  B43.16}P 66.851 2.673 9.024
{ c3  su2   1000  B45.15}66.028 3.754 8.776
{ c4  su2   1000  B40.74}P 65.659 5.883 10.230
{ c5  su2   1000  B38.30}66.033 6.468 11.430
{ c6  su2   1000  B39.89}66.950 5.839 12.283
{ c7  su2   1000  B41.27}67.522 4.632 11.961
{ n1  su2   1000  B41.46}P 67.514 2.841 10.212
{ c8  su2   1000  B40.96}67.142 4.039 10.760
{ c3  su2   1000  B45.15}P 66.028 3.754 8.776
{ c9  su2   1000  B43.35}66.211 4.641 9.884
{ c3  su2   1000  B45.15}P 66.028 3.754 8.776
{ c10 su2   1000  B50.85}65.125 4.031 7.577
{ c1' su2   1000  B55.18}64.496 2.993 6.663
{ c2' su2   1000  B58.09}63.501 3.369 5.771
{ c3' su2   1000  B61.98}62.919 2.433 4.921
{ c4' su2   1000  B65.02}63.324 1.101 4.946
{ c5' su2   1000  B61.90}64.321 0.732 5.845
{ c1' su2   1000  B55.18}P 64.496 2.993 6.663
{ c6' su2   1000  B56.61}64.899 1.666 6.694
{ n1* su2   1000  B77.52}P 61.495 -2.035 2.458
{ c11 su2   1000  B79.63}60.886 -3.175 1.843
{ o3  su2   1000  B82.84}59.685 -3.436 1.791
{ n1* su2   1000  B77.52}P 61.495 -2.035 2.458
{ c2* su2   1000  B76.02}62.921 -2.113 2.946
{ c3* su2   1000  B72.01}63.593 -0.802 3.300
{ c4' su2   1000  B65.02}P 63.324 1.101 4.946
{ n4* su2   1000  B69.45}62.743 0.142 4.081
{ c5* su2   1000  B72.77}61.357 0.308 3.540
{ n1* su2   1000  B77.52}P 61.495 -2.035 2.458
{ c6* su2   1000  B75.93}60.655 -0.994 3.158
{ c7  su2   1000  B41.27}P 67.522 4.632 11.961
{ c8  su2   1000  B40.96}67.142 4.039 10.760
{ c4  su2   1000  B40.74}P 65.659 5.883 10.230
{ c9  su2   1000  B43.35}66.211 4.641 9.884
{ c8  su2   1000  B40.96}P 67.142 4.039 10.760
{ c9  su2   1000  B43.35}66.211 4.641 9.884
{ c5' su2   1000  B61.90}P 64.321 0.732 5.845
{ c6' su2   1000  B56.61}64.899 1.666 6.694
{ c3* su2   1000  B72.01}P 63.593 -0.802 3.300
{ n4* su2   1000  B69.45}62.743 0.142 4.081
{ c5* su2   1000  B72.77}P 61.357 0.308 3.540
{ c6* su2   1000  B75.93}60.655 -0.994 3.158
{ n1  su2   1001  B40.50}P 5.763 2.531 20.322
{"}5.763 2.531 20.322
{ c2  su2   1001  B40.11}6.434 2.994 21.427
{ o2  su2   1001  B36.41}6.373 2.382 22.494
{ c2  su2   1001  B40.11}P 6.434 2.994 21.427
{ c3  su2   1001  B41.97}7.095 4.165 21.131
{ c4  su2   1001  B37.17}P 7.197 5.445 18.850
{ c5  su2   1001  B35.31}6.724 5.400 17.547
{ c6  su2   1001  B35.46}5.890 4.356 17.114
{ c7  su2   1001  B37.23}5.517 3.338 17.955
{ n1  su2   1001  B40.50}P 5.763 2.531 20.322
{ c8  su2   1001  B40.40}5.988 3.383 19.272
{ c3  su2   1001  B41.97}P 7.095 4.165 21.131
{ c9  su2   1001  B41.23}6.824 4.424 19.740
{ c3  su2   1001  B41.97}P 7.095 4.165 21.131
{ c10 su2   1001  B47.02}7.942 5.053 22.036
{ c1' su2   1001  B54.37}8.750 4.616 23.254
{ c2' su2   1001  B58.87}9.710 5.470 23.781
{ c3' su2   1001  B60.77}10.461 5.100 24.898
{ c4' su2   1001  B62.10}10.264 3.868 25.513
{ c5' su2   1001  B57.95}9.298 3.017 24.982
{ c1' su2   1001  B54.37}P 8.750 4.616 23.254
{ c6' su2   1001  B56.28}8.548 3.386 23.863
{ n1* su2   1001  B73.20}P 12.493 2.711 29.152
{ c11 su2   1001  B76.38}13.263 2.277 30.281
{ o3  su2   1001  B80.37}14.236 2.845 30.785
{ n1* su2   1001  B73.20}P 12.493 2.711 29.152
{ c2* su2   1001  B70.94}11.764 1.713 28.306
{ c3* su2   1001  B68.84}10.669 2.264 27.421
{ c4' su2   1001  B62.10}P 10.264 3.868 25.513
{ n4* su2   1001  B66.39}11.030 3.489 26.650
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{ c6* su2   1001  B71.32}12.819 3.991 28.426
{ c7  su2   1001  B37.23}P 5.517 3.338 17.955
{ c8  su2   1001  B40.40}5.988 3.383 19.272
{ c4  su2   1001  B37.17}P 7.197 5.445 18.850
{ c9  su2   1001  B41.23}6.824 4.424 19.740
{ c8  su2   1001  B40.40}P 5.988 3.383 19.272
{ c9  su2   1001  B41.23}6.824 4.424 19.740
{ c5' su2   1001  B57.95}P 9.298 3.017 24.982
{ c6' su2   1001  B56.28}8.548 3.386 23.863
{ c3* su2   1001  B68.84}P 10.669 2.264 27.421
{ n4* su2   1001  B66.39}11.030 3.489 26.650
{ c5* su2   1001  B69.35}P 11.751 4.522 27.468
{ c6* su2   1001  B71.32}12.819 3.991 28.426
@kinemage 2
@caption

 View1: The two lobes of FGFR1K connected by the hinge region(residues 563 through 568).
 View2: The cleft between the two lobes to which ATP binds.
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{R2 gly b 485 }64.787 7.019 2.646
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{  R1 gly b 487 }P T 63.677 12.889 4.265
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{R1 ala b 488 }63.004 16.982 5.363
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{R2 ala b 488 }62.432 16.779 6.021
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{R1 ala b 488 }P T 63.154 17.846 5.467
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{R1 phe b 489 }64.202 19.522 5.620
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{R2 phe b 489 }64.325 19.378 6.461
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{  R1 phe b 489 }P T 63.776 19.239 5.574
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{R1 phe b 489 }P T 64.202 19.522 5.620
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{R1 phe b 489 }P T 64.672 19.403 5.681
{R2 phe b 489 }T 64.970 19.333 6.490
{R1 phe b 489 }P T 65.149 18.957 5.742
{R2 phe b 489 }T 65.614 18.981 6.500
{R1 phe b 489 }P T 65.592 18.293 5.777
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{  R1 gly b 490 }P 65.592 18.293 5.777
{R1 gly b 490 }65.959 17.522 5.765
{"}66.225 16.737 5.686
{"}66.414 15.946 5.551
{"}66.566 15.139 5.377
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{R2 gly b 490 }66.787 17.679 6.446
{"}67.265 16.883 6.376
{"}67.665 16.048 6.282
{"}67.993 15.197 6.173
@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
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{  R1 gly b 539 }P T 72.835 6.073 26.460
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{  R1 leu b 547 }P T 72.586 3.416 17.752
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{R1 leu b 548 }76.377 3.695 16.397
{"}77.070 3.774 15.950
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{  R2 leu b 548 }P 75.339 3.934 15.768
{R2 leu b 548 }75.963 4.109 15.465
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{  R1 leu b 548 }P T 75.664 3.660 16.814
{  R2 leu b 548 }T 75.339 3.934 15.768
{R1 leu b 548 }P T 76.377 3.695 16.397
{R2 leu b 548 }T 75.963 4.109 15.465
{R1 leu b 548 }P T 77.070 3.774 15.950
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{R1 leu b 548 }P T 77.730 3.930 15.490
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{  R1 gly b 549 }P 78.341 4.198 15.035
{R1 gly b 549 }78.885 4.610 14.603
{"}79.353 5.187 14.206
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{  R2 gly b 549 }P 77.650 4.733 14.626
{R2 gly b 549 }78.114 5.106 14.352
{"}78.515 5.615 14.070
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{  R1 gly b 549 }P T 78.341 4.198 15.035
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{R1 gly b 549 }P T 78.885 4.610 14.603
{R2 gly b 549 }T 78.114 5.106 14.352
{R1 gly b 549 }P T 79.353 5.187 14.206
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{R1 gly b 549 }P T 79.754 5.887 13.832
{R2 gly b 549 }T 78.864 6.234 13.766
{R1 gly b 549 }P T 80.102 6.652 13.462
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{R1 ala b 550 }80.415 7.427 13.079
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{  R1 ala b 550 }P T 80.102 6.652 13.462
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{R1 cys b 551 }81.492 10.237 11.550
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{R2 cys b 551 }80.598 10.485 11.226
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{  R1 cys b 551 }P T 81.238 9.558 11.880
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@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
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{R1 glu b 670 }P T 46.768 16.071 28.162
{R2 glu b 670 }T 46.876 14.522 28.885
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{R2 glu b 670 }T 48.228 15.092 28.939
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{R1 ala b 671 }49.836 17.272 28.101
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{R2 ala b 671 }49.596 15.429 28.080
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{R1 leu b 672 }50.082 17.835 24.681
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{R2 leu b 672 }49.300 16.198 25.108
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{R1 leu b 672 }P T 50.082 17.835 24.681
{R2 leu b 672 }T 49.300 16.198 25.108
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{R1 leu b 672 }P T 47.723 19.109 23.958
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{  R1 phe b 673 }P 47.723 19.109 23.958
{R1 phe b 673 }47.053 19.639 24.357
{"}46.680 20.162 25.066
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{R2 phe b 673 }46.871 18.084 25.406
{"}46.608 18.573 26.075
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@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 phe b 673 }P T 47.723 19.109 23.958
{  R2 phe b 673 }T 47.369 17.567 24.943
{R1 phe b 673 }P T 47.053 19.639 24.357
{R2 phe b 673 }T 46.871 18.084 25.406
{R1 phe b 673 }P T 46.680 20.162 25.066
{R2 phe b 673 }T 46.608 18.573 26.075
{R1 phe b 673 }P T 46.607 20.634 25.951
{R2 phe b 673 }T 46.584 19.017 26.831
{R1 phe b 673 }P T 46.808 21.004 26.855
{R2 phe b 673 }T 46.781 19.406 27.536
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{R1 asp b 674 }47.258 21.226 27.618
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{"}48.724 21.154 28.391
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{R2 asp b 674 }47.182 19.725 28.051
{"}47.759 19.963 28.278
{"}48.452 20.110 28.287
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@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
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{R1 asp b 674 }P T 47.921 21.266 28.119
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{R2 asp b 674 }T 48.452 20.110 28.287
{R1 asp b 674 }P T 49.586 20.936 28.505
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{  R1 arg b 675 }P 49.586 20.936 28.505
{R1 arg b 675 }50.425 20.656 28.535
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{R2 arg b 675 }49.912 20.087 28.094
{"}50.556 19.900 28.090
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@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 arg b 675 }P T 49.586 20.936 28.505
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{R1 arg b 675 }P T 50.425 20.656 28.535
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{R1 arg b 675 }P T 51.174 20.350 28.540
{R2 arg b 675 }T 50.556 19.900 28.090
{R1 arg b 675 }P T 51.833 20.016 28.545
{R2 arg b 675 }T 51.129 19.604 28.171
{R1 arg b 675 }P T 52.417 19.641 28.561
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{R1 ile b 676 }52.943 19.213 28.601
{"}53.425 18.724 28.674
{"}53.875 18.181 28.775
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{  R2 ile b 676 }P 51.651 19.213 28.307
{R2 ile b 676 }52.142 18.739 28.468
{"}52.618 18.198 28.630
{"}53.083 17.606 28.782
{"}53.535 16.979 28.918
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{  R1 ile b 676 }P T 52.417 19.641 28.561
{  R2 ile b 676 }T 51.651 19.213 28.307
{R1 ile b 676 }P T 52.943 19.213 28.601
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{R1 ile b 676 }P T 53.425 18.724 28.674
{R2 ile b 676 }T 52.618 18.198 28.630
{R1 ile b 676 }P T 53.875 18.181 28.775
{R2 ile b 676 }T 53.083 17.606 28.782
{R1 ile b 676 }P T 54.304 17.592 28.897
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{  R1 tyr b 677 }P 54.304 17.592 28.897
{R1 tyr b 677 }54.725 16.968 29.032
{"}55.143 16.317 29.175
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{  R2 tyr b 677 }P 53.535 16.979 28.918
{R2 tyr b 677 }53.974 16.335 29.033
{"}54.399 15.685 29.125
{"}54.808 15.029 29.205
{"}55.197 14.360 29.292
@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 tyr b 677 }P T 54.304 17.592 28.897
{  R2 tyr b 677 }T 53.535 16.979 28.918
{R1 tyr b 677 }P T 54.725 16.968 29.032
{R2 tyr b 677 }T 53.974 16.335 29.033
{R1 tyr b 677 }P T 55.143 16.317 29.175
{R2 tyr b 677 }T 54.399 15.685 29.125
{R1 tyr b 677 }P T 55.549 15.635 29.333
{R2 tyr b 677 }T 54.808 15.029 29.205
{R1 tyr b 677 }P T 55.930 14.919 29.520
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@vectorlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 thr b 678 }P 55.930 14.919 29.520
{R1 thr b 678 }56.272 14.164 29.746
{"}56.560 13.370 30.018
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{"}56.913 11.746 30.647
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{  R2 thr b 678 }P 55.197 14.360 29.292
{R2 thr b 678 }55.563 13.672 29.401
{"}55.899 12.958 29.546
{"}56.189 12.206 29.720
{"}56.409 11.405 29.914
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{  R1 thr b 678 }P T 55.930 14.919 29.520
{  R2 thr b 678 }T 55.197 14.360 29.292
{R1 thr b 678 }P T 56.272 14.164 29.746
{R2 thr b 678 }T 55.563 13.672 29.401
{R1 thr b 678 }P T 56.560 13.370 30.018
{R2 thr b 678 }T 55.899 12.958 29.546
{R1 thr b 678 }P T 56.779 12.556 30.324
{R2 thr b 678 }T 56.189 12.206 29.720
{R1 thr b 678 }P T 56.913 11.746 30.647
{R2 thr b 678 }T 56.409 11.405 29.914
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{  R1 his b 679 }P 56.913 11.746 30.647
{R1 his b 679 }56.946 10.962 30.968
{"}56.862 10.236 31.267
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{R2 his b 679 }56.541 10.543 30.120
{"}56.559 9.630 30.324
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{  R1 his b 679 }P T 56.913 11.746 30.647
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{R2 his b 679 }T 56.541 10.543 30.120
{R1 his b 679 }P T 56.862 10.236 31.267
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{  R1 gln b 680 }P 56.302 9.184 31.659
{R1 gln b 680 }55.805 8.982 31.676
{"}55.171 9.050 31.531
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{"}53.934 9.642 30.778
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{  R2 gln b 680 }P 56.095 8.065 30.638
{R2 gln b 680 }55.529 7.654 30.697
{"}54.721 7.612 30.655
{"}53.814 7.856 30.478
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{  R1 gln b 680 }P T 56.302 9.184 31.659
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{R2 gln b 680 }T 53.814 7.856 30.478
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{  R1 ser b 681 }P 53.934 9.642 30.778
{R1 ser b 681 }53.582 9.949 30.190
{"}53.539 10.129 29.493
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{  R2 ser b 681 }P 52.984 8.263 30.128
{R2 ser b 681 }52.413 8.709 29.568
{"}52.230 9.080 28.791
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{  R1 ser b 681 }P T 53.934 9.642 30.778
{  R2 ser b 681 }T 52.984 8.263 30.128
{R1 ser b 681 }P T 53.582 9.949 30.190
{R2 ser b 681 }T 52.413 8.709 29.568
{R1 ser b 681 }P T 53.539 10.129 29.493
{R2 ser b 681 }T 52.230 9.080 28.791
{R1 ser b 681 }P T 53.736 10.141 28.774
{R2 ser b 681 }T 52.375 9.297 27.913
{R1 ser b 681 }P T 54.067 9.958 28.138
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{  R1 asp b 682 }P 54.067 9.958 28.138
{R1 asp b 682 }54.423 9.551 27.688
{"}54.706 8.916 27.498
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{"}54.797 7.395 27.682
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{  R2 asp b 682 }P 52.739 9.288 27.078
{R2 asp b 682 }53.213 8.983 26.432
{"}53.691 8.347 26.086
{"}54.064 7.496 26.011
{"}54.229 6.582 26.144
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{  R1 asp b 682 }P T 54.067 9.958 28.138
{  R2 asp b 682 }T 52.739 9.288 27.078
{R1 asp b 682 }P T 54.423 9.551 27.688
{R2 asp b 682 }T 53.213 8.983 26.432
{R1 asp b 682 }P T 54.706 8.916 27.498
{R2 asp b 682 }T 53.691 8.347 26.086
{R1 asp b 682 }P T 54.851 8.156 27.522
{R2 asp b 682 }T 54.064 7.496 26.011
{R1 asp b 682 }P T 54.797 7.395 27.682
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{  R1 val b 683 }P 54.797 7.395 27.682
{R1 val b 683 }54.488 6.759 27.902
{"}53.896 6.350 28.106
{"}53.127 6.164 28.223
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{  R2 val b 683 }P 54.229 6.582 26.144
{R2 val b 683 }54.079 5.757 26.419
{"}53.552 5.148 26.767
{"}52.760 4.779 27.079
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{  R1 val b 683 }P T 54.797 7.395 27.682
{  R2 val b 683 }T 54.229 6.582 26.144
{R1 val b 683 }P T 54.488 6.759 27.902
{R2 val b 683 }T 54.079 5.757 26.419
{R1 val b 683 }P T 53.896 6.350 28.106
{R2 val b 683 }T 53.552 5.148 26.767
{R1 val b 683 }P T 53.127 6.164 28.223
{R2 val b 683 }T 52.760 4.779 27.079
{R1 val b 683 }P T 52.317 6.172 28.180
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{  R1 trp b 684 }P 52.317 6.172 28.180
{R1 trp b 684 }51.604 6.347 27.908
{"}51.101 6.646 27.366
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{  R2 trp b 684 }P 51.858 4.646 27.241
{R2 trp b 684 }51.000 4.747 27.137
{"}50.322 5.058 26.693
{"}49.877 5.464 25.989
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{  R1 trp b 684 }P T 52.317 6.172 28.180
{  R2 trp b 684 }T 51.858 4.646 27.241
{R1 trp b 684 }P T 51.604 6.347 27.908
{R2 trp b 684 }T 51.000 4.747 27.137
{R1 trp b 684 }P T 51.101 6.646 27.366
{R2 trp b 684 }T 50.322 5.058 26.693
{R1 trp b 684 }P T 50.831 6.969 26.642
{R2 trp b 684 }T 49.877 5.464 25.989
{R1 trp b 684 }P T 50.792 7.203 25.852
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{  R1 ser b 685 }P 50.792 7.203 25.852
{R1 ser b 685 }50.985 7.234 25.116
{"}51.383 6.980 24.532
{"}51.869 6.487 24.130
{"}52.296 5.830 23.921
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{  R2 ser b 685 }P 49.698 5.831 25.147
{R2 ser b 685 }49.821 6.022 24.289
{"}50.244 5.932 23.524
{"}50.834 5.580 22.918
{"}51.425 5.013 22.523
@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 ser b 685 }P T 50.792 7.203 25.852
{  R2 ser b 685 }T 49.698 5.831 25.147
{R1 ser b 685 }P T 50.985 7.234 25.116
{R2 ser b 685 }T 49.821 6.022 24.289
{R1 ser b 685 }P T 51.383 6.980 24.532
{R2 ser b 685 }T 50.244 5.932 23.524
{R1 ser b 685 }P T 51.869 6.487 24.130
{R2 ser b 685 }T 50.834 5.580 22.918
{R1 ser b 685 }P T 52.296 5.830 23.921
{R2 ser b 685 }T 51.425 5.013 22.523
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{  R1 phe b 686 }P 52.296 5.830 23.921
{R1 phe b 686 }52.523 5.086 23.916
{"}52.440 4.331 24.105
{"}52.081 3.641 24.386
{"}51.513 3.093 24.633
@vectorlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R2 phe b 686 }P 51.425 5.013 22.523
{R2 phe b 686 }51.849 4.281 22.394
{"}51.973 3.444 22.551
{"}51.797 2.605 22.883
{"}51.352 1.880 23.245
@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 phe b 686 }P T 52.296 5.830 23.921
{  R2 phe b 686 }T 51.425 5.013 22.523
{R1 phe b 686 }P T 52.523 5.086 23.916
{R2 phe b 686 }T 51.849 4.281 22.394
{R1 phe b 686 }P T 52.440 4.331 24.105
{R2 phe b 686 }T 51.973 3.444 22.551
{R1 phe b 686 }P T 52.081 3.641 24.386
{R2 phe b 686 }T 51.797 2.605 22.883
{R1 phe b 686 }P T 51.513 3.093 24.633
{R2 phe b 686 }T 51.352 1.880 23.245
@vectorlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 gly b 687 }P 51.513 3.093 24.633
{R1 gly b 687 }50.805 2.763 24.723
{"}50.033 2.698 24.560
{"}49.305 2.831 24.170
{"}48.738 3.065 23.607
@vectorlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R2 gly b 687 }P 51.352 1.880 23.245
{R2 gly b 687 }50.672 1.383 23.493
{"}49.812 1.196 23.509
{"}48.914 1.260 23.285
{"}48.142 1.487 22.841
@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 gly b 687 }P T 51.513 3.093 24.633
{  R2 gly b 687 }T 51.352 1.880 23.245
{R1 gly b 687 }P T 50.805 2.763 24.723
{R2 gly b 687 }T 50.672 1.383 23.493
{R1 gly b 687 }P T 50.033 2.698 24.560
{R2 gly b 687 }T 49.812 1.196 23.509
{R1 gly b 687 }P T 49.305 2.831 24.170
{R2 gly b 687 }T 48.914 1.260 23.285
{R1 gly b 687 }P T 48.738 3.065 23.607
{R2 gly b 687 }T 48.142 1.487 22.841
@vectorlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 val b 688 }P 48.738 3.065 23.607
{R1 val b 688 }48.446 3.303 22.928
{"}48.508 3.459 22.192
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{R1 val b 688 }P T 48.446 3.303 22.928
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{R2 leu b 689 }49.017 2.012 19.173
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{R1 trp b 691 }P T 47.137 -0.221 18.772
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{  R1 glu b 692 }P T 47.137 -0.221 18.772
{  R2 glu b 692 }T 46.405 -1.641 17.814
{R1 glu b 692 }P T 47.399 -0.137 18.050
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{R1 glu b 692 }P T 47.886 -0.301 17.483
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{R1 glu b 692 }P T 48.481 -0.695 17.096
{R2 glu b 692 }T 47.744 -1.613 15.702
{R1 glu b 692 }P T 49.040 -1.276 16.900
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{  R1 ile b 693 }P 49.040 -1.276 16.900
{R1 ile b 693 }49.422 -2.000 16.901
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{  R1 ile b 693 }P T 49.040 -1.276 16.900
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{R1 ile b 693 }P T 49.516 -2.814 17.087
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{  R1 phe b 694 }P T 48.932 -4.340 17.608
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{R1 thr b 695 }P T 45.788 -4.915 15.520
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{R1 thr b 695 }P T 45.957 -4.894 14.882
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{R1 leu b 696 }P T 46.866 -4.764 13.684
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{R1 leu b 696 }P T 47.476 -4.579 13.172
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{R1 leu b 696 }P T 48.065 -4.302 12.737
{R2 leu b 696 }T 47.768 -4.446 11.405
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{  R1 gly b 697 }P 48.520 -3.942 12.387
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{  R2 gly b 697 }P 48.320 -4.148 10.885
{R2 gly b 697 }48.612 -3.714 10.545
{"}48.568 -3.097 10.410
{"}48.246 -2.352 10.435
{"}47.735 -1.555 10.557
@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 gly b 697 }P T 48.520 -3.942 12.387
{  R2 gly b 697 }T 48.320 -4.148 10.885
{R1 gly b 697 }P T 48.728 -3.510 12.129
{R2 gly b 697 }T 48.612 -3.714 10.545
{R1 gly b 697 }P T 48.615 -3.012 11.967
{R2 gly b 697 }T 48.568 -3.097 10.410
{R1 gly b 697 }P T 48.253 -2.453 11.880
{R2 gly b 697 }T 48.246 -2.352 10.435
{R1 gly b 697 }P T 47.749 -1.837 11.847
{R2 gly b 697 }T 47.735 -1.555 10.557
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{  R1 gly b 698 }P 47.749 -1.837 11.847
{R1 gly b 698 }47.214 -1.167 11.842
{"}46.734 -0.450 11.850
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{  R2 gly b 698 }P 47.735 -1.555 10.557
{R2 gly b 698 }47.125 -0.783 10.713
{"}46.493 -0.094 10.856
{"}45.878 0.525 10.997
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@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 gly b 698 }P T 47.749 -1.837 11.847
{  R2 gly b 698 }T 47.735 -1.555 10.557
{R1 gly b 698 }P T 47.214 -1.167 11.842
{R2 gly b 698 }T 47.125 -0.783 10.713
{R1 gly b 698 }P T 46.734 -0.450 11.850
{R2 gly b 698 }T 46.493 -0.094 10.856
{R1 gly b 698 }P T 46.319 0.295 11.880
{R2 gly b 698 }T 45.878 0.525 10.997
{R1 gly b 698 }P T 45.958 1.049 11.951
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{  R1 ser b 699 }P 45.958 1.049 11.951
{R1 ser b 699 }45.640 1.791 12.080
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{"}45.063 3.188 12.545
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{  R2 ser b 699 }P 45.304 1.105 11.165
{R2 ser b 699 }44.799 1.677 11.387
{"}44.378 2.264 11.687
{"}44.010 2.857 12.071
{"}43.656 3.440 12.541
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{  R1 ser b 699 }P T 45.958 1.049 11.951
{  R2 ser b 699 }T 45.304 1.105 11.165
{R1 ser b 699 }P T 45.640 1.791 12.080
{R2 ser b 699 }T 44.799 1.677 11.387
{R1 ser b 699 }P T 45.351 2.503 12.279
{R2 ser b 699 }T 44.378 2.264 11.687
{R1 ser b 699 }P T 45.063 3.188 12.545
{R2 ser b 699 }T 44.010 2.857 12.071
{R1 ser b 699 }P T 44.745 3.849 12.869
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{  R1 pro b 700 }P 44.745 3.849 12.869
{R1 pro b 700 }44.365 4.491 13.240
{"}43.904 5.116 13.639
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{  R2 pro b 700 }P 43.656 3.440 12.541
{R2 pro b 700 }43.276 3.995 13.099
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{  R1 pro b 700 }P T 44.745 3.849 12.869
{  R2 pro b 700 }T 43.656 3.440 12.541
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{R1 pro b 700 }P T 43.904 5.116 13.639
{R2 pro b 700 }T 42.841 4.508 13.726
{R1 pro b 700 }P T 43.380 5.706 13.997
{R2 pro b 700 }T 42.370 4.973 14.317
{R1 pro b 700 }P T 42.824 6.238 14.235
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{  R1 tyr b 701 }P 42.824 6.238 14.235
{R1 tyr b 701 }42.266 6.690 14.273
{"}41.734 7.048 14.051
{"}41.247 7.329 13.593
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{  R2 tyr b 701 }P 41.897 5.385 14.746
{R2 tyr b 701 }41.452 5.740 14.887
{"}41.058 6.038 14.651
{"}40.697 6.296 14.102
{"}40.339 6.535 13.342
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{  R1 tyr b 701 }P T 42.824 6.238 14.235
{  R2 tyr b 701 }T 41.897 5.385 14.746
{R1 tyr b 701 }P T 42.266 6.690 14.273
{R2 tyr b 701 }T 41.452 5.740 14.887
{R1 tyr b 701 }P T 41.734 7.048 14.051
{R2 tyr b 701 }T 41.058 6.038 14.651
{R1 tyr b 701 }P T 41.247 7.329 13.593
{R2 tyr b 701 }T 40.697 6.296 14.102
{R1 tyr b 701 }P T 40.821 7.560 12.941
{R2 tyr b 701 }T 40.339 6.535 13.342
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{  R1 pro b 702 }P 40.821 7.560 12.941
{R1 pro b 702 }40.475 7.767 12.141
{"}40.215 7.974 11.250
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{  R2 pro b 702 }P 40.339 6.535 13.342
{R2 pro b 702 }39.956 6.775 12.472
{"}39.532 7.040 11.590
{"}39.099 7.360 10.789
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@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 pro b 702 }P T 40.821 7.560 12.941
{  R2 pro b 702 }T 40.339 6.535 13.342
{R1 pro b 702 }P T 40.475 7.767 12.141
{R2 pro b 702 }T 39.956 6.775 12.472
{R1 pro b 702 }P T 40.215 7.974 11.250
{R2 pro b 702 }T 39.532 7.040 11.590
{R1 pro b 702 }P T 40.017 8.205 10.394
{R2 pro b 702 }T 39.099 7.360 10.789
{R1 pro b 702 }P T 39.845 8.480 9.712
{R2 pro b 702 }T 38.703 7.768 10.156
@vectorlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 gly b 703 }P 39.845 8.480 9.712
{R1 gly b 703 }39.666 8.822 9.342
{"}39.457 9.246 9.380
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{"}39.088 10.314 10.266
@vectorlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R2 gly b 703 }P 38.703 7.768 10.156
{R2 gly b 703 }38.390 8.298 9.780
{"}38.192 8.967 9.719
{"}38.102 9.734 9.912
{"}38.099 10.544 10.265
@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 gly b 703 }P T 39.845 8.480 9.712
{  R2 gly b 703 }T 38.703 7.768 10.156
{R1 gly b 703 }P T 39.666 8.822 9.342
{R2 gly b 703 }T 38.390 8.298 9.780
{R1 gly b 703 }P T 39.457 9.246 9.380
{R2 gly b 703 }T 38.192 8.967 9.719
{R1 gly b 703 }P T 39.249 9.747 9.734
{R2 gly b 703 }T 38.102 9.734 9.912
{R1 gly b 703 }P T 39.088 10.314 10.266
{R2 gly b 703 }T 38.099 10.544 10.265
@vectorlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 val b 704 }P 39.088 10.314 10.266
{R1 val b 704 }39.018 10.933 10.838
{"}39.070 11.595 11.338
{"}39.232 12.290 11.755
{"}39.479 13.009 12.102
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{  R2 val b 704 }P 38.099 10.544 10.265
{R2 val b 704 }38.164 11.342 10.688
{"}38.281 12.083 11.103
{"}38.451 12.770 11.503
{"}38.679 13.413 11.896
@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 val b 704 }P T 39.088 10.314 10.266
{  R2 val b 704 }T 38.099 10.544 10.265
{R1 val b 704 }P T 39.018 10.933 10.838
{R2 val b 704 }T 38.164 11.342 10.688
{R1 val b 704 }P T 39.070 11.595 11.338
{R2 val b 704 }T 38.281 12.083 11.103
{R1 val b 704 }P T 39.232 12.290 11.755
{R2 val b 704 }T 38.451 12.770 11.503
{R1 val b 704 }P T 39.479 13.009 12.102
{R2 val b 704 }T 38.679 13.413 11.896
@vectorlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 pro b 705 }P 39.479 13.009 12.102
{R1 pro b 705 }39.784 13.743 12.391
{"}40.122 14.484 12.640
{"}40.460 15.232 12.878
{"}40.765 15.987 13.137
@vectorlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R2 pro b 705 }P 38.679 13.413 11.896
{R2 pro b 705 }38.973 14.028 12.289
{"}39.329 14.625 12.692
{"}39.724 15.217 13.126
{"}40.124 15.813 13.611
@ribbonlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 pro b 705 }P T 39.479 13.009 12.102
{  R2 pro b 705 }T 38.679 13.413 11.896
{R1 pro b 705 }P T 39.784 13.743 12.391
{R2 pro b 705 }T 38.973 14.028 12.289
{R1 pro b 705 }P T 40.122 14.484 12.640
{R2 pro b 705 }T 39.329 14.625 12.692
{R1 pro b 705 }P T 40.460 15.232 12.878
{R2 pro b 705 }T 39.724 15.217 13.126
{R1 pro b 705 }P T 40.765 15.987 13.137
{R2 pro b 705 }T 40.124 15.813 13.611
@vectorlist {ribbon} color= {coil} nobutton master= {ribbon}
{  R1 val b 706 }P 40.765 15.987 13.137
{R1 val b 706 }41.002 16.751 13.448
{"}41.139 17.512 13.830
{"}41.133 18.207 14.248
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