6 1057 DLG1_RAT ---------- ---MPVRKQD TQRALHLLEE YRSKLSQTED RQLRSSIERV DLG4_HUMAN ---------- ---MSQRPRA PRSALWLLAP PLLRWAPP-- ---------L DLG3_MOUSE ---------- ---MHKHQHC CKCPECYEVT RLAALRRLEP PGYG-DWQVP CSKP_HUMAN -----MADDD VLFEDVYELC EVIGKGPFSV VRRCINRETG QQFAVKIVDV CAKI_DROME -----MTEDE IVFDDVYELC EVIGKGPFSI VRRCIHRESN QQFAVKIVDV LIN2_CAEEL MRELDPDESN LLLDEQLSIR DVIEQGPFSN VYRILHGPSN RKFLLRSINL ISIFQSNLFQ ALIDIQEFYE VTLLDNPKCV DHSKQCEPVQ PGNPWESGSL LTVLHSDLFQ ALLDILDYYE ASLSES---- ---------- ---------- DPYGPSGGNG ASSGYGGYSS QTLPSQAG-- ---------- ---------- AKFTSSPGLS TEDLKREASI CHMLKHPHIV ELLETYSS-- ---------- AKFTASPGLS TADLKREATI CHMLKHPHIV ELLETYSS-- ---------- NLFRQHTGLG FEEIDEEIRI CQNLQHPYIC RLEKTINS-- ---------- SSAAVTSESL PGGLSPPVEK YRYQDEEVLP SERISPQVPN EVLGPELVHV ---------- --------QK YRYQDEDTPP LEHSPAHLPN ---------- ---------- ------ATPT PRTKAKLIPT GRDVGPVPPK PVPGK----- DGMLYMVFEF MDGADLCFEI VKRADAGFVY SEAVASHYMR QILEALRYCH EGMLYMVFEF MEGSDLCFEV VRRAVAGFVY SEAVACHYMR QILEALRYCH VHYRHIIFEN MEGNDICFEI VQRASNGFVF SEYVVSHYTR QLLDALDYCH SEKSLSEIEN VHGFVSHSHI SPIKPTEAVP PSSPIVPVTP ALPVPAESPV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -STPKLNGSG PGWWPECTCT DNNIIHRDVK PHCVLLASKE NS-------- -APVKLGGFG VAIQLG--ES ENEILHRDVR PACALLATVD NS-------- -APVKLGGFG SAIQLPGTRE TRKIVHRDVR PHNLVLASKD TS-------- -APLKLCGFG VAKDLS-EIG VLPSTPQANP PPVLVNTDSL ETP---TYVN GTDADYEYEE ITLERGNSGL ------QANS PPVIVNTDTL EAPGYELQVN GTEGEMEYEE ITLERGNSGL NRDWYEQASP APLLVNPEAL EPS---LSVN GSDGMFKYEE IVLERGNSGL GLVAGGRVGT PHFMAPEVVK REPYGKPVDV WGCGVILFIL LSGCLPFYGT TIETHGRVGC PHYMAPEVVT RRLYGKGCDV WGAGVMLHVL LSGRLPFLGS GSMACGRVGV PQFMAPEIVR KDRVSCSSDI WSSGVVLFLL LAGRLPFSGS GFSIAGGTDN ---------- PHIGDDSSIF ITKIITGG-A AAQDGRLRVN GFSIAGGTDN ---------- PHIGDDPSIF ITKIIPGG-A AAQDGRLRVN GFSIAGGIDN ---------- PHVPDDPGIF ITKIIPGG-A AAMDGRLGVN KERLFEGIIK GKYKMNPRQW SHISESAKDL VRRMLMLDPA ERITVYEALN GVRLQQSVAR GRLSFEAPEW KSISANAKDL VMKMLAANPH HRLSITEVLD TSDIYERIMQ TDVDVDG-YM PNISESARNL VRRMLNADPS KRISAKEALN DCILRVNEAD VRDVTHSKAV EALKEAGSIV RLYVKRRK-A FRKNHEIKLI DSILFVNEVD VREVTHSAAV EALKEAGSIV RLYVMRRKPP AEKVMEIKLI DCVLRVNEVD VSEVVHSRAV EALKEAGPVV RLVVRRRQPP PETIMEVNLL HPWLKERDRY AYKIHLPETV EQLRKFNARR KLKGAVLAAV SSHKFNSFYG HPWIRDRDK- LQRTHLADTV EELKRYNARR KLKGAVQAIA GGTNMDPLYA HEWIRDKEHM ASRKHMNDVI DQMRRYNESR KLKSNVLSAV NSGRFDETTP KGPKGLGFSI AGG------- ---------- ---------- --------VG KGPKGLGFSI AGG------- ---------- ---------- --------VG KGPKGLGFSI AGG------- ---------- ---------- --------IG DPPEELPDFS EDP------- ---TSSGLLA AERAVSQ--- ----VLDSLE T-DADMPITG ATD------- ---EWADEEA GIEAVQR--- ----ILDCLD RQDTPQTAFV DGSSPGGDCC HRGESSSNDA AEPPADKDLS GAYKVLGSLD NQHIPGDNSI YVTKIIEGGA AHKDG----K LQIGDKLLAV NSVCLEEVTH NQHIPGDNSI YVTKIIEGGA AHKDG----R LQIGDKILAV NSVGLEDVMH NQHIPGDNSI YITKIIEGGA AQKDG----R LQIGDRLLAV NNTNLQDVRH EIHALTDCSE --KDLDFLHS VFQDQHLHTL LDLYDKIN-T KSSPQIRNPP DIYSLQDAH- --VDADVLRD MLRDNRLHQF LQLFDRIAAT VVTSNGRAPA AINSLLDPNS YKPGSTTFQK IHDDGSVRNL LRLYDKIKAL PCEPVVTEVD EEAVTALKNT SDFVYLKAAK PT------SM YINDGYAPPD ITNSSSQSVD EDAVAALKNT YDVVYLKVAK PS------NA YLSDSYAPPD ITTSYSQHLD EEAVASLKNT SDMVYLKVAK PG------SI HLNDMYAPPD YASTFTALAD SDAVQRAKEV LEEISCYPEN N------DAK ELKRILTQPH FMALLQTHDV AEAVGRCRDV LEQLSSTSGG NSLGGKYAKE ELMRLLAAPH MQALLHSHDV TSTLR--KET LNQIDGLLGP SP-----EAL ELRQLLNSPH LASCVQALDV NHVSPSS--- ---YLG---- --QTPAS--- -PARYSPISK AVLGDDEITR NEISHSS--- ---YLGTDYP TAMTPTS--- -PRRYSPVAK DLLGEEDIPR NHISHNSS-- -LGYLGAVES KVTYPAPPQV PPTRYSPIPR HMLAEEDFTR VAHEVYS--- -------DEA LRVTPPPTSP YLNGDSP--E SANGGMDMEN VARDVYG--- -------EEA AR-HPAPDGA LPQWREL--D NVEGG-ELQH VVCEIRDPKN EASGSGDKEG NCVSSDPAPA YLNGGVLPLG AQRAGTSFEH E--------- ---------- ---PRKVVLH RGSTG-LGFN IVGGEDGEGI E--------- ---------- ---PRRIVIH RGSTG-LGFN IVGGEDGEGI E--------- ---------- ---PRKIILH KGSTG-LGFN IVGGEDGEGI V--------- ---------- -TRVRLVQFQ KNTDEPMGIT LKMNELNH-C V--------- ---------- -TRVRLVHFQ KNTDEPMGIT LKMTEDGR-C FNQSAVHTSY DEEEEELYDC MSRLRLVQFQ KDTQEPMGIT LKVNEDGR-C FISFILAGGP ADLSGELRKG DRIISVNSVD LRAASHEQAA AALKNAG--Q FISFILAGGP ADLSGELRKG DQILSVNGVD LRNASHEQAA IALKNAG--Q FVSFILAGGP ADLSGELRRG DRILSVNGVN LRNATHEQAA AALKRAG--Q IVARIMHGGM IHRQGTLHVG DEIREINGIS VANQTVEQLQ KMLREMRGSI IVARLMHGGM IHRQATLHVG DEIREINGQP VQHQSVGQLQ RMLREARGSV FVARIMHGGM IHRQATLHVG DEIREINGMS VANRSVESLQ EMLRDARGQV AVTIVAQYRP EEYSRFEAKI HDLRETMMNS SVSSGSG--- --SLRTSQKR TVTIIAQYKP EEYSRFEAKI HDLREQLMNS SLGSGTA--- --SLRSNPKR SVTIVAQYRP EEYSRFESKI HDLREQMMNS SMSSGSG--- --SLRTSEKR TFKIVPSYRT QSSSCERDSP STSRQSPANG HSSTNNSVSD LPSTTQPKGR TFKIVPSYRS APPPCE---- ---------- ---------- ---------- TFKIIPSYRS APPACE---- ---------- ---------- ---------- SLYVRALFDY DKTKDSGLPS --QGLNFKFG DILHVINASD DEWWQARQVT GFYIRALFDY DKTKDCGFLS --QALSFRFG DVLHVIDASD EEWWQARRVH SLYVRALFDY DRTRDSCLPS --QGLSFSYG DILHVINASD DEWWQARLVT QIYVRAQFEY DPAKDDLIPC KEAGIRFRVG DIIQIISKDD HNWWQGKLEN -IFVRAQFDY NPLDDELIPC AQAGISFQVG DILQIISKDD HHWWQARLG- -IFVRAQFDY EPSQDDLIPC PQAGIPFKTG DILQVISKDD HNWWQARFVS ---PDGESDE ---------V GVIPSKRRVE KKERARLKTV KFNSKTRGDK ---SDSETDD ---------I GFIPSKRRVE RREWSRLKAK DWGSSS---- ---PHGESEQ ---------I GVIPSKKRVE KKERARLKTV KFHARTGMIE ---SKNGT-- ---------A GLIPSSELQE WRVACIAMEK TKQEQQ---- ---TVGGS-- ---------A GLIPSPELQE WRIACQTVDK TKQEQ----- SFPSIGNSSN AQRSNQQQVA GLIPSPELQE WRTACLAMER SKNTCN---- ------GEIP DDMGSKGLKH VTSNASDSES SYHEYGCSKG GQEEYVLSYE ---------- ---GSQ---- ---------- ---------- GREDSVLSYE SNRDFPGLSD DYYGAKNLKG VTSNTSDSES SSK------- GQEDAILSYE -------ASC TWFGKKKKQY KDKYLAKHN- ---------- ---ADLVTYE -------VNC SIFGRKKKQC RDKYLAKHNA IFD------- --TLDVVTYE -------THC MWFNKKKKYY TTKYLQKHSA LFD------- --QLDLVTYE PVNQQEVN-- --YTRPVIIL GPM---KDRV NDDLISEFPD KFGSCVPHTT TVTQMEVH-- --YARPIIIL GPT---KDRA NDDLLSEFPD KFGSCVPHTT PVTRQEIH-- --YARPVIIL GPM---KDRV NDDLISEFPH KFGSCVPHTT EVVKLPA--- -FKRKTLVLL GAHGVGRRHI KNTLITKHPD RFAYPIPHTT EVVKVPVGDP NFQRKTLVLL GAHGVGRRHI KNTLISKYPD KYVYPIPHTT EVMRLSQ--- -YRRKTLVLL GAHGVGRRHI KNTLIHRHPN RFAYPIPHTT RPKRDYEVDG RDYHFVTSRE QMEKDIQEHK FIEAGQYNNH LYGTSVQSVR RPKREYEIDG RDYHFVSSRE KMEKDIQAHK FIEAGQYNSH LYGTSVQSVR RPRRDNEVDG QDYHFVVSRE QMEKDIQDNK FIEAGQFNDN LYGTSIQSVR RPPKRDEENG KNYYFVS-HD QMMQDISNNE YLEYGSHEDA MYGTKLETIR RPAKPEEENG RSYYFVS-HD EMMADIGANE YLEYGTHEDA MYGTKLDTIR RPPRKDEVDG KHYYFVT-NE QMMADIQNNE YLEYGTHEES MYGTKLETIR AVAEKGKHCI LDVSGNAIKR LQIAQLYPIS IFIKPKSMEN IMEMNKRLTD EVAEQGKHCI LDVSANAVRR LQAAHLHPIA IFIRPRSLEN VLEINKRITE AVAERGKHCI LDVSGNAIKR LQQAQLYPIA IFIKPKSIEA LMEMNRRQTY KIHEQGLIAI LDVEPQALKV LRTAEFAPFV VFIAAPTITP GLNED----- RIHTEGKMAI LDVEPQALKI LRTAEFTPYV VFIAAPSLQN IADYD----- NIHKSGKIAI LDVEPQALKV LRTAEYSPFV VFIAAPNLQG MQDPD----- EQARKTFERA VRLEQEFTEH FTAIVQGDTL EDIYNQVKQI IEEQSGPYIW EQARKAFDRA TKLEQEFTEC FSAIVEGDSF EEIYHKVKRV IEDLSGPYIW EQANKIFDKA MKLEQEFGEY FTAIVQGDSL EEIYNKIKQI IEDQSGHYIW ESLQRLQKES DILQRTYAHY FDLTIINNEI DETIRHLEEA VELVCTAPQW GSLERLAKES EMLRQLYGHF FDLTIVNNDI SETIATLETA IDRVHTTPQW GSLEKLLNES DVLRQAFGHL FDFIITNSDI DDTIAQLERL VEKLPAYPQW 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