Course Announcement
Fall 2004

last modified: 9/24/04

Current Topics in Protein Structure and Chemistry

Course Director: Samuel J. Landry, Ph.D., Department of Biochemistry

Class will meet weekly in the Biochemistry Departement Conference Room (6301) for two hours to discuss current and classic papers selected from the primary literature by the course director. One paper per week will be analyzed in depth in order to appreciate (1) identification of a research problem, (2) design of an experimental approach, (3) technical limitations, and (4) interpretation of data. A broad range of experimental systems and strategies will be covered, with the common thread being post-translational modification, localization, and degradation of proteins. The time and location of class meetings will be determined in consultation with course participants.
 

Register for GBCH 701 (2 hrs.) with the help of Tynette Hills in the Biochemistry Dept. Office.

An organizational meeting will be held Tuesday, Aug. 31st at 5pm in order to select a day/time for future class meetings.

 

MONTH
DATE
DAY/TIME
REFERENCE
TITLE
APPENDICES
August
31
Tuesday/5:00p.m.
 Organizational Meeting

September
7
Tue.
  Wood MJ, Storz G, Tjandra N.
Nature. 2004 Aug 19;430(7002):917-21.

 Structural basis for redox regulation of Yap1 transcription factor localization.
 Molecular Cell Biology by Lodish et al. (Fifth Edition) pp. 68-73, 165-173, 509-518, 601-605

Aslund F, Beckwith J. Bridge over troubled waters: sensing stress by disulfide bond formation.
Cell. 1999 Mar 19;96(6):751-3. Review.

PDB: 1SSE

14
Tue.
 Hurricane Ivan scare


21
Tue.
 Kadokura H, Tian H, Zander T, Bardwell JC, Beckwith J.
Science. 2004 Jan 23;303(5657):534-7. 		Abstract     Snapshots of DsbA in action: detection of proteins in the process of oxidative folding. Crystal structure of DsbA (PDB: 1FVK)

NMR structure of human thioredoxin complexed with Ref-1 peptide (PDB: 1CQH)

28
Tue.
 Masip L, Pan JL, Haldar S, Penner-Hahn JE, DeLisa MP, Georgiou G, Bardwell JC, Collet JF. Science. 2004 Feb 20;303(5661):1185-9 An engineered pathway for the formation of protein disulfide bonds.
October
5
Tue.
 Wu PY, Hanlon M, Eddins M, Tsui C, Rogers RS, Jensen JP, Matunis MJ, Weissman AM, Wolberger CP, Pickart CM. EMBO J. 2003 Oct 1;22(19):5241-50 A conserved catalytic residue in the ubiquitin-conjugating enzyme family. Pickart CM. Mechanisms underlying ubiquitination. Annu Rev Biochem. 2001;70:503-33. Review.

12
Tue.
 Lam YA, Lawson TG, Velayutham M, Zweier JL, Pickart CM.  Nature. 2002 Apr 18;416(6882):763-7. A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal.

19
Tue.
 Hierro A, Sun J, Rusnak AS, Kim J, Prag G, Emr SD, Hurley JH.Nature. 2004 Aug 25 Structure of the ESCRT-II endosomal trafficking complex.
 
26
Tue.

Helenius A, Aebi M.  Roles of N-linked glycans in the endoplasmic reticulum.
Annu Rev Biochem. 2004;73:1019-49.
November
2
Tue.



9
Tue.



16
Tue.

Mann RK, Beachy PA.  Novel lipid modifications of secreted protein signals.
Annu Rev Biochem. 2004;73:891-923.
 
23
Tue.



30
 Tue.