Cell 607

Reading Assignments and List of Terms

Reading Assignments:

• Alberts, Ch. 10, Membrane Structure
• Alberts, Ch. 12, Intracellular Compartments and Protein Sorting
• Alberts, Ch. 13, Vesicular Traffic in the Secretory and Endocytic Pathways
• Alberts, Ch. 5, Protein Function
• Richard K. Plemper, Sigrun Böhmler, Javier Bordallo, Thomas Sommer & Dieter H. Wolf  (1997) MUTANT ANALYSIS LINKS THE TRANSLOCON AND BIP TO RETROGRADE PROTEIN TRANSPORT FOR ER DEGRADATION. Nature 388: 891 - 895 [Abstract] [Full Text]

 

Supplemental Reading (Current Reviews):

• Mattaj and Englmeier (1998) NUCLEOCYTOPLASMIC TRANSPORT: THE SOLUBLE PHASE. Annu. Rev. Biochem. 67: 265-306  [Abstract]
• Schatz and Dobberstein (1996) COMMON PRINCIPLES OF PROTEIN TRANSLOCATION ACROSS MEMBRANES. Science 271: 1519-1526 [Abstract]
• Schekman and Orci (1996) COAT PROTEINS AND VESICLE BUDDING. Science 271: 1526-1533 [Abstract]
• Nikolaus Pfanner, Elizabeth A. Craig, and Angelika Hönlinger (1997) MITOCHONDRIAL PREPROTEIN TRANSLOCASE. Annu. Rev. Cell Dev. Biol. 13: 25-51. [Abstract] [Full Text]

List of Terms

Ch. 10, Membrane Structure

• plasma membrane
• lipid bilyaer
• phospholipid
• head group
• hydrocarbon tail
• liposome
• micelle
• prenyl group
• GPI anchor
• peripheral membrane protein
• integral membrane protein
• single-pass transmembrane protein
• hydropathy plot
• bacteriorhodopsin
• porin
• lectin

 

Ch. 12, Intracellular Compartments and Protein Sorting

• organelle
• lumen
• nucleus
• cytoplasm
• cytosol
• endoplasmic reticulum
• Golgi apparatus
• mitochondrion
• mitochondrial matrix
• mitochondrial intermembrane space
• mitochondrial inner membrane
• mitochondrial outer membrane
• mitochondrial contact sites
• chloroplast
• chloroplast stroma
• chloroplast thylakoid
• lysosome
• vacuole
• endosome
• peroxisome
• topological equivalence
• sorting signal
• signal peptide (or signal sequence)
• signal peptidase
• default pathway
• nuclear pore
• nuclear localization signal
• nuclear lamina
• precursor protein
• amphipathic helix
• Hsp70
• BiP
• co-translational translocation
• post-translational translocation
• rough endoplasmic reticulum
• smooth endoplasmic reticulum
• free ribosomes
• signal recognition particle (SRP)
• SRP receptor (SR)
• stop-transfer signal
• single-pass transmembrane protein
• multi-pass transmembrane protein
• positive-inside rule
• glycoprotein
• glycosylation
• glycosylphosphatidylinositol (GPI) anchor
• flippase
• phospholipid transfer protein
• Golgi stacks
• cis Golgi compartment
• trans Golgi compartment
• ER retention signal
• brefeldin A
• N-linked oligosaccharide
• high-mannose oligosaccharide
• complex oligosaccharide
• O-linked glycosylation
• proteoglycan
• acid hydrolase
• mannose 6-phosphate
• lysosomal storage disease
• receptor-mediated endocytosis
• phagocytosis
• clathrin coated pit
• clathrin coated vesicle
• early endosomes
• late endosomes
• vacuolar H+ ATPase
• transcytosis
• exocytosis
• default pathway
• secretory vesicles
• synaptic vesicles
• coatomer-coated vesicles
• COPII
• COPI
• adaptin
• ADP-ribosylated factor (ARF)
• LDL receptor
• transferrin
• EGF receptor
• constitutive secretory pathway
• regulated secretory pathway
• SNARE
• Rab protein
• SNAP
• NEM-sensitive factor