Hammerhead Mechanism

References:

The hammerhead ribozyme coordinates Mg++ in the proper geometry to stabilize the trigonal bipyramid intermediate formed by attack of the 2´-OH on the phosphate. The end products are a 2´,3´ cyclic phosphate and a 5´-OH.

hammin.GIF

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Comments or Suggestions to:Jim Nolan at jnolan@tulane.edu