Education:

1989-1993

Ph.D., Department of Biology, University of Iowa
Study field: Developmental Biology
Thesis title: "Role of retinoic acid in vertebrate axis formation"
Advisor: Dr. Michael Solursh
 

1985-1988

Ph.D. candidate, Shanghai Institute of Cell Biology
Academia Sinica, P.R.China
Study field: Developmental Biology
Advisor: Dr. Hsiao-Hui Chuang
 

1982-1985

M.S., Department of Biology, Fujian Normal University
P.R.China
Study field: Developmental Biology
Advisor: Dr. Han-Po Ting
 

1978-1982

B.S., Department of Biology, Fujian Normal University
P.R.China
Study field: Biology
 

Postdoctoral training:

1995-1996

Postdoctoral Fellow,
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
Advisor:  Dr. Richard Maas

1994-1995

Research Associate,
Howard Hughes Medical Institute, Brigham and Women's Hospital and Harvard Medical School
Advisor: Dr. Richard Maas

1993-1994

Research Investigator,
Department of Biological Sciences, University of Iowa
Dr. Michael Solursh
 

Academic Appointments:

Publications: 

Original research articles:

1. Chen, YP, Solursh, M. The determination of myogenic and cartilage cells in the early chick embryo and the modifying effect of retinoic acid. Roux's Archives Dev. Biol. 1991; 200:162-171.

2. Chen, YP, Solursh, M. A comparison of Henson's node and retinoic acid in secondary axis induction in the early chick embryo. Dev.Dynam. 1992; 195:142-151.

3. Chen, YP, Huang, L, Russo, AF, Solursh, M. Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chick embryo. Proc.Natl.Acad. Sci. USA 1992; 89:10056-10059.

4. Chen, YP, Huang, L, Solursh, M. A concentration gradient of retinoids in the early Xenopus laevis embryos. Dev. Biol. 1994; 161:70-76.

5. Shen, RQ*, Chen, YP*, Huang, L, Vitale, E, Solursh, M. Characterization of the human Msx-1 promoter and an enhancer responsible for the induction of retinoic acid. Cell. Mol. Biol. Res. 1994; 40:297-312. (*: equal first author)

6. Chen, YP, Kostetskii, I, Zile, MH, Solursh, M. Comparative study of Msx-1 expression in early normal and vitamin A-deficient avian embryos. J. Exp. Zool.1995; 272:299-310.

7. Chen, YP, Solursh, M. Mirror-image duplication of the primary axis and heart in Xenopus embryo by overexpression of Msx-1 gene. J. Exp. Zool. 1995; 273:170-174.

8. Chen, YP, Dong, D, Kostetskii, I, Zile, MH. Hensen's node from vitamin A-deficient quail embryo induces chick limb duplication and retains its normal asymmetrical expression of Sonic hedgehog (Shh). Dev. Biol. 1996; 173:265-264.

9. Chen, YP, Bei, M, Woo, I, .Satokata, I, Maas, R. Msx1 controls inductive signaling during mammalian tooth morphogenesis. Development 1996; 122:3035-3044.

10. Maas, R, Chen, YP, Bei M, Woo, I, Satokata, I. The role of Msx genes in mammalian development. Ann. N.Y. Acad. Sci. 1996; 785:171-181.

11. St. Amand, TR, Jin, R, Zhang, YD, Hu, YP, Baber, SI, Qiu, MS and Chen, YP. Cloning and expression pattern of chicken Pitx2: A new component in the SHH signaling pathway controlling embryonic heart looping. Biochem. Biophys. Res. Commun. 1998; 247:100-105.

12. Li, CJ, Slaven, WT.IV, Chen, YP and John, VT. In aqua synthesis of a high molecular weight areneethynylene polymer. Chem. Commun. 1998; 1351-1352.

13. Zhang, YD, Zhao, X, Hu, YP, St. Amand, T, Zhang, MF, Ramamurthy, R, Qiu, MS. and Chen, YP. Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ. Dev. Dynam. 1999; 215:45-53.

14. Slaven, WT.IV, Li, CJ, Chen, YP. John, VT. and Rachakonda, SH. In aqua synthesis of a high molecular weight arylethynylene polymer exhibiting reversible hydrogel properties. J. Macromole. Sci. Pure Appl. Chem. 1999; A36(7&8):971-980.

15. Cai, J*, St.Amand, TR*, Yin, H, Guo, H, Li, G, Zhang, YD, Chen, YP, and Qiu, MS. Expression and regulation of the chicken Nkx-6.2 homeobox gene suggests its possible involvement in the ventral neural patterning and cell fate specification. Dev. Dynam. 1999; 216:459-468. (*: equal first author)

16. St. Amand, TR, Zhang, YD, Semina, E, Hu, YP, Zhao, X, Murray, J and Chen, YP. Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth forming anlage. Dev. Biol. 2000; 217:323-332.

17. Zhang, YD*, Zhang, ZY*, Zhao, X, Yu, XY, Hu, YP, Fromm, SH and Chen, YP. A new function of BMP4: Dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ. Development 2000; 127:1431-1443.

18. Zhang, ZY*, Yu, XY*, Zhang, YD, Geronimo, B, Lovlie, A, Fromm, SH and Chen, YP. Targeted misexpression of constitutively active BMP receptor-IB causes bifurcation and duplication and posterior transformation of digit in mouse limb. Dev. Biol. 2000; 220:154-167. (*: equal first author)

19. Zile, MH, Kostetskii, I, Yuan, S, Kostetskaia, E, St. Amand, TR, Chen, YP, and Jiang, W. Retinoid signaling is required to complete vertebrate cardiac left-right asymmetry pathway. Dev. Biol. 2000; 223:323-338..

20. Cai, J, Yin, H, Chen, YP and Qiu, MS. Nkx-6.1 homeobox gene is expressed in esophanus mesenchyme, ventral spinal meninges and a subset of motoneurons. Genesis 2000; 27:6-11.

21. Chen, YP, Zhang, YD, Jiang, T-X, Barlow, AJ, St.Amand, TR, Hu, YP, Francis-West, P, Chuong, C-M and Maas, R. Conservation of early odontogenic signaling pathways in Aves. Proc. Natl. Acad. Sci. USA 2000; 97:10044-10049.

22. Zhao, X,* Zhang, ZY,* Zhang, YD, Hu, YP, Zhang, X., Fromm, SH. and Chen, YP. Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression and partially rescues tooth phenotype. Mech. Dev. 2000; 99:29-38. (*: equal first author).

23. Yu, XY*, St. Amand, TR*, Wang, S, Li, G, Zhang, YD, Hu, YP, Nguyen, L, Qiu, MS and Chen, YP. Differential expression and functional analysis of Pitx2 isoforms in regulation of heart looping in the chick. Development 2001; 128:1005-1013. (*: equal first author).

24. Linask, KK., Yu, XY., Chen, YP., and Han, MD. Directionality of heart looping: Effects of Pitx2c misexpression on flectin asymmetry and midline structures. Dev. Biol. 2002; 246:407-417.

25. Zhang, ZY, Song, YQ, Zhao, X, Zhang, X, Fermin, C. and Chen, YP. Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and SHH signaling in the regulation of mammalian palatogenesis. Development 2002; 129:4135-4146.

26. Zhang, YD, Wang, SS, Song, YQ, Han, J, Chai, Y, and Chen, YP. Timing of odontogenic neural crest cell migration and tooth-forming capability in mice. Dev. Dynam. 2003; 226:713-718.

27. Zhang, ZY, Zhang, XY, Avniel, WA, Song, YQ, Jones, SM, Jones, TA, Fermin, C. and Chen, YP. The malleal processus brevis is dispensable for normal hearing in mice. Dev. Dynam. 2003; 227:69-77.

28. Zhang, ZY, Song, YQ, Zhang, XY, Tnag, J, Chen, J, Chen, YP. Msx1/BMP4 genetic pathway regulates mammalian alveolar bone formation via induction of Dlx5 and Cbfa1. Mech. Dev. 2003; 120:1469-1479. 

29. Suzuki, K, Bachiller, D, Chen, YP, Kamikawa, M, Ogi, H, Haraguchi, R, Ogino, Y, Minami, Y, Mishina, Y, Ahn, K, Crenshaw, EB, Yamada, G. Regulation of outgrowth and apoptosis for the terminal appendage, external genitalia, development by concerted functions of Bmp signaling. Development 2003; 130:6209-6220. 

30.  Wang SS, Yu XY, Zhang T, Lin W, Zhang XY, Zhang ZY, Chen YP.  cPcl2 regulates the left-right asymmetry by repressing Shh expression in Hensen’s node.  Development 2004 (In press)

31.  Alappat S, Zhang ZY, Suzuki K, Zhang XY, Liu HB, Jiang RL, Yamada G, Chen YP.  The cellular and molecular etiology of cleft secondary palate in Fgf10 mutant mice. Dev. Biol. 2004; (in revision).


 

Book chapters and review articles:

1. Bei, M, Chen, YP, Woo, I, Satokata, I. Maas, R. Control of murine tooth development by the Msx genes. In "The Biological Mechanisms of Tooth Movement and Craniofacial Adaptation" by Z. Davidovitch, 1996; p431-439. Harvard Society for the Advancement of Orthodontics, Boston, MA. USA.

2. Chen, YP. and Maas, R. Signaling loops in the reciprocal epithelial-mesenchymal interactions of mammalian tooth development. In "Molecular Basis of Epithelial Appendage Morphogenesis" ed. C-M. Chuong, R.G. Landes, Austin, TX, 1998; pp265-282.

3. Chen, YP, and Zhao, X. Shaping limbs by apoptosis. J. Exp. Zool. 1998; 282:691-702.

4. Chuong, C-M, Hou, L, Chen, PJ, Wu, P, Patel, N, and Chen, YP. Dinosaur's feather and chicken tooth? Tissue engineering of the integument. Eur. J. Dermatol. 2001; 11:286-292.

5. Yu, XY, Wang, S., Chen, YP. Expression and Function of Pitx2 in Chick Heart Looping. In "The Molecular Mechanisms of Rieger Syndrome", Ed. B.A. Amendt, R.G. Landes, Austin, TX. 2003; (In press).

6. Alappat, S, Zhang, ZY, Chen, YP. (2003). Msx homeobox gene family and craniofacial development. Cell Res. 2003; (In press)
 

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