Publications



2016

Liu J, Wang M, Tulman D, Mandava SH, Elfer KN, Gabrielson A, Lai W, Abshire C, Sholl AB, Brown JQ, Lee BR. “Non-destructive diagnosis of kidney cancer on 18-gauge core needle renal biopsy using dual-color fluorescence structured illumination microscopy,” Urology, dx.doi.org/10.1016/j.urology.2016.08.036. 2016.

Chitalia R, Mueller J, Fu HL, Whitley MJ, Kirsch DG, Brown JQ, Willett R, Ramanujam N. “Algorithms for differentiating between images of heterogeneous tissue across fluorescence microscopes.” Biomedical Optics Express, 7(9):3412-3424. 2016.

Wang M, Tulman DB, Sholl AB, Kimbrell HZ, Mandava SH, Elfer KN, Luethy S, Maddox MM, Lai W, Lee BR, Brown JQ. “Gigapixel surface imaging of radical prostatectomy specimens for comprehensive detection of cancer-positive surgical margins using structured illumination microscopy.” Scientific Reports, 6:27419. 2016.

Frazier TP, Bowles A, Lee S, Abbott R, Tucker HA, Kaplan D, Wang M, Strong A, Brown Q, He J, Bunnell BA, Gimble JM, “Serially transplanted non-pericytic CD146- adipose stromal/stem cells in silk bioscaffolds regenerate adipose tissue in vivo,” Stem Cells, 34(4):1097-1111. 2016.

Fu HL, Mueller JL, Whitley MJ, Cardona DM, Willett RM, Kirsch DG, Brown JQ, Ramanujam N, “Structured illumination microscopy and a quantitative image analysis for the detection of positive margins in a pre-clinical genetically engineered mouse model of sarcoma, “ PLoS ONE, 11(1): e0147006. 2016


2015

Wang M, Kimbrell HZ, Sholl AB, Tulman DB, Elfer KN, Schlichenmeyer TC, Lee BR, Lacey M, Brown JQ, “High-resolution rapid diagnostic imaging of whole prostate biopsies using video-rate fluorescence structured illumination microscopy,” Cancer Research, 75(19): 4032-4041. 2015. *Recommended by F1000Prime

Frazier TP, Bowles A, Lee S, Abbott R, Tucker HA, Kaplan D, Wang M, Strong A, Brown Q, He J, Bunnell BA, Gimble JM, “Serially transplanted non-pericytic CD146- adipose stromal/stem cells in silk bioscaffolds regenerate adipose tissue in vivo,” Stem Cells, in press. 2015.


2014

Goel UO, Maddox MM, Elfer KN, Dorsey P, Wang M, McCaslin R, Brown JQ*, Lee BR. “Feasibility of quantitative diffuse reflectance spectroscopy for targeted measurement of renal ischemia during laparoscopic partial nephrectomy,” Journal of Biomedical Optics, 19(10), 107001. 2014. *corresponding author

Schlichenmeyer TC, Wang M, Elfer KN, Brown JQ, “Video-rate structured illumination microscopy for high-throughput imaging of large tissue areas,” Biomedical Optics Express, 5(2): 366-377. 2014.

Wang M, Tulman D, Schlichenmeyer TC, Elfer KN, Kimbrell H, Brown JQ, “Video-rate structured illumination microscopy for rapid point-of-care pathology imaging,” OSA BIOMED Meeting, Miami, FL. paper BW1A.5, 2014.

Schlichenmeyer TC, Wang M, Wenk C, Brown JQ, “Autofocus optimization for tracking tissue surface topography in large area mosaicking structured illumination microscopy,” OSA Frontiers in Optics, Tucson, AZ. OSA Technical Digest, paper FM4F.3. 2014.

Wang M, Tulman D, Schlichenmeyer TC, Kimbrell H, Brown JQ, “Rapid diagnosis of whole prostate core-needle biopsies with video-rate structured illumination microscopy,” OSA Frontiers in Optics, Tucson, AZ. OSA Technical Digest, paper FW1E.2. 2014.


2013

Fu HL, Mueller JL, Javid M, Mito J, Kirsch DG, Ramanujam N, Brown JQ, “Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma,” PLOS ONE8(7): e68868. 2013.

Brown JQ, Bydlon TM, Kennedy SA, Gallagher J, Caldwell M, Junker M, Wilke LG, Barry WT, Geradts J, Ramanujam N, “Optical surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins,” PLOS ONE, 8(7): e69906. 2013.  

Mueller J, Harmany Z, Mito J, Kim Y, Geradts J, Kirsch D, Willett R, Brown JQ, Ramanujam N, “Quantitative segmentation of fluorescence microscopy images of heterogeneous tissue: Application to the detection of residual disease in tumor margins,” PLOS ONE, 8(6): e66198. 2013.  

Lo J, Brown JQ, Dhar S, Yu B, Jokerst NM, Ramanujam N, “Wavelength optimization for quantitative spectroscopic imaging of breast tumor margins,” PLOS ONE, 8(4):e61767. 2013.


2012 and prior

Bydlon TM, Barry WT, Kennedy SA, Brown JQ, Gallagher JE, Wilke LG, Geradts J, and Ramanujam N. “Advancing optical imaging for breast tumor margin assessment: a systematic analysis of excisional time, cautery, and LymphazurinTM on underlying sources of optical contrast,” PLOS ONE , 7(12):e51418, 2012.

Millon SR, Ostrander JH, Brown JQ, Rajeha A, Ramanujam N, “Uptake of 2-NBDG as a method to monitor therapy response in breast cancer cell lines,” Breast Cancer Research and Treatment, 126:55-62, 2011.

Kennedy SA, Geradts J, Bydlon TM, Brown JQ, Gallagher J, Junker M, Barry WT, Ramanujam N, Wilke LG, “Optical breast cancer margin assessment: An observational study on the effects of tissue heterogeneity on optical contrast,” Breast Cancer Research and Treatment, 12:R91, 2010.

Brown JQ, Bydlon TM, Richards LM, Yu B, Kennedy SA, Wilke LG, Geradts J, Junker M, Gallagher J, Ramanujam N, “Optical assessment of tumor resection margins in the breast,” Invited paper, IEEE Journal of Selected Topics on Quantum Electronics, 16:530-544. 2010.

Ostrander JH, McMahon CM, Lem S, Millon S, Brown JQ, Seewaldt V, Ramanujam N., “Optical redox-ratio differentiates breast cancer cell lines based on receptor status,” Cancer Research, 70:4759-66, 2010.

Bydlon TM, Kennedy SA, Richards LM, Brown JQ, Yu B, Junker MK, Gallagher J, Geradts J, Wilke LG, Ramanujam N., “Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins,” Optics Express, 18:8058-8076, 2010.

Millon SR, Ostrander JH, Yazdanfar S, Brown JQ, Bender JE, Rajeha A, Ramanujam N., “Preferential accumulation of ALA-induced PpIX in breast cancer: A comprehensive study on six breast cell lines,” Journal of Biomedical Optics, Vol. 15, 018002 (Feb. 18, 2010).

Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, Junker M, Gallagher J, Barry WT, Geradts J, Ramanujam N, “Rapid non-invasive optical imaging of tissue composition in breast tumor margins.” American Journal of Surgery, 198:566-574, 2009.

Brown JQ, Vishwanath K, Palmer GM, Ramanujam N., “Advances in quantitative UV-visible spectroscopy for clinical and pre-clinical application in cancer,” Current Opinion in Biotechnology , 20:119-131, 2009.

Brown JQ, Wilke LG, Geradts J, Kennedy S, Palmer GM, Ramanujam N, “Quantitative optical spectroscopy: A robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo,” Cancer Research, 69:2919-2926, 2009.

Bender JE, Vishwanath K, Moore LK, Brown JQ, Chang V, Palmer GM, Ramanujam, N. “A Robust Monte Carlo Model for the Extraction of Biological Absorption and Scattering in Vivo,” IEEE Trans BME, 56:960-968, 2009.

Brown JQ, Wilke LG, Geradts J, Kennedy S, Palmer GM, Ramanujam N, “Quantitative optical spectroscopy: A robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo,” Cancer Research, 69:2919-2926, 2009.

Bender JE, Vishwanath K, Moore LK, Brown JQ, Chang V, Palmer GM, Ramanujam, N. “A Robust Monte Carlo Model for the Extraction of Biological Absorption and Scattering in Vivo,” IEEE Trans BME, 56:960-968, 2009.

Brown JQ, Srivastava R, Zhu H, McShane MJ, “Enzymatic Fluorescent Microsphere Glucose Sensors: Evaluation of Response Under Dynamic Conditions,” Diabetes Technology and Therapeutics, 8:288-295. 2006.

Brown JQ, McShane MJ, “Modeling of Spherical Enzymatic Fluorescent Glucose Microsensor Systems: Design of Smart Tattoos,” Biosensors and Bioelectronics, 21:1760-1769. 2006.

Zhu H, Srivastava R, Brown JQ, McShane MJ, “Combined Physical and Chemical Immobilization of Glucose Oxidase in Alginate Microspheres Improves Stability of Encapsulation and Activity,” Bioconjugate Chemistry, 16:1451-1458. 2005.
Brown JQ, Srivastava R, McShane MJ, “Encapsulation of Glucose Oxidase and an Oxygen-Quenched Fluorophore in Polyelectrolyte-Coated Calcium Alginate Microspheres as Optical Glucose Sensor Systems,” Biosensors and Bioelectronics, 21:212-216. 2005.

Brown JQ, McShane MJ, “Core-Referenced Ratiometric Potassium Ion Sensors Using Self-Assembled Ultrathin Films on Europium Nanoparticles,” IEEE Sensors Journal, 5:1197-1205. 2005.

Brown JQ, McShane MJ, “Nanoengineered Polyelectrolyte Micro- and Nano-Capsules as Fluorescent Potassium Ion Sensors,” IEEE-EMBS Magazine, 22:118-123. 2003.

McShane MJ, Brown JQ, Guice KB, Lvov YM, "Polyelectrolyte Microshells as Carriers for Fluorescent Sensors: Loading and Sensing Properties of a Ruthenium-Based Oxygen Indicator," Journal of Nanoscience and Nanotechnology, 2: 411-416. 2002.

Duchesne TA, Brown JQ, Guice KB, Lvov YM, McShane MJ, "Encapsulation and Stability Properties of Nanoengineered Polyelectrolyte Capsules for use as Fluorescent Sensors," Sensors and Materials, 14:293-308. 2002.


Book Chapters



Brown JQ, Vishwanath K, Chang V, Palmer GM, Ramanujam N, “Clinical applications of UV-VIS spectroscopy in head and neck, cervical, and breast cancers,” in In Vivo Clinical Imaging and Diagnosis, Ed. James Tunnell, McGraw-Hill, New York. pp. 239-285, 2011.

Vishwanath K, Palmer GM, Brown JQ, Ramanujam N, “Non-invasive and quantitative sensing of tumor physiology and function via steady-state diffuse optical spectroscopy,” in Biosensors and Molecular Technologies for Cancer Diagnostics , Ed. KE Herold and A Rasooly, CRC Press, 2012.