Practical wide-field optical sectioning microscopy

Surgical removal of the tumor is the first and best treatment option for non-metastatic cancers. However, in many organ sites it is challenging to determine the completeness of tumor removal, due to lack of available intra-operative technologies to assist surgeons and pathologists in detection of residual tumor. We are developing practical optical sectioning microscopy solutions using fluorescence contrast for intra-operative assessment of tumor margins. Our mission is to help patients avoid unnecessary repeat surgeries and reduce worries about recurrent tumors.

Quantitative optical tissue spectroscopy

Biological tissue interacts with light energy in ways that allows us to peer into the underlying physiology and tissue composition. The challenge is to isolate these complex interactions quantitatively, so that we can use them appropriately. We are adapting quantitative spectroscopy systems to address a variety of issues in clinical cancer therapy, for example, quantification of ischemia during kidney tumor removal, and on-line in vivo monitoring of experimental cancer therapies.