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Pretest 2008 2008 Syllabus 2008 Assignments Historic Test Problems BMEN 602 Biosystems 3 credit hours This course gives students the skills to interpret or predict the behavior of physiologic systems in order to study normal and pathologic phenomena. The body uses many feedback control mechanisms to maintain homeostasis, the keeping of a constant interior environment (eg. pH, temperature, blood pressure, balance, bone stress, muscle length). Transfer functions characterize organ physiology. These functions are the building blocks of an organ system model. By studying these models, complex behavior can often be easily interpreted. Further, these models often suggest ways to make noninvasive physiologic measurements. Applications include: vicious cycles, such as hyperventilation syndrome, and how to break them; hierarchical, parallel, and other redundant systems; causes of instabilities such as Cheyne-Stokes breathing; open and closed loop control of anesthesia and artificial organs. Reference will be made to several common mechanisms such as the thermostat. Lecture demonstrations include pulmonary and cardiovascular measurement. A term paper on a topic of the student's choice is required. Prerequisite: BMEN306(706) or equivalent Term Paper Examples Textbooks: J. J. DiStefano, A. R. Stubberud, I. J. Williams, Feedback Control Systems, 2nd Ed., McGraw Hill (Schaum's Outline Series), New York, 1994 Reference (not required): J. H. Milsum, Biological Control Systems Analysis, McGraw Hill, New York, 1966 Khoo, M.C. Physiological control systems, IEEE Press, 1999 J. Van de Vegte, Feedback Control Systems, Prentice-Hall, Englewood Cliffs, New Jersey, 1986 A. C. Guyton, Textbook of Medical Physiology, 10th edition, Saunders, Philadelphia, 2000 Instructor: David A. Rice, Ph.D., P.E. 522 Boggs Center 865 5898 BMEN602 Biosystems Educational Objectives Given a description of a physiologic control system, the student will be able to describe the system and its function in terms of block diagrams. Using block diagram algebra, the student will be able simplify the system representation and to predict system behavior. The student will be able to characterize the input-output relationship of a block diagram transfer function in both the time and frequency (s-) domains. The student will be able to determine whether a system uses open or closed loop control as well as whether it has positive or negative feedback. The student will be able to assess the type of stability the system exhibits. The student will be able to demonstrate methods for the determination of physiologic variables, such as flow rates or volume, from indirect measurements. ABET criteria # chits a 1 b 2 e 1 g 1 i 1 l 1 m 2