Biochemistry 601

September 13, 1996 Protein Tertiary and Quaternary Structure

Last modified 9/12/96.

Dr. Landry
Rm. 6055
landry@mailhost.tcs.tulane.edu

Recognize that protein structures can be presented in different ways: alpha-carbon trace, backbone, stick, ribbon, CPK (Cory-Purcell-Koshland).
Understand the hierarchy of protein structure: primary, secondary, tertiary, quaternary.
Appreciate the diversity of tertiary structure types and know that there are common classes, e.g., four-helix bundle, beta barrel, TIM barrel.
Recognize common themes in protein structure/function relationships, e.g., DNA binding often is mediated by alpha-helices, and enzyme active sites occur at the C-terminus of beta-strands in alpha/beta proteins (such as triose phosphate isomerase).

File #4 - TERTIARY STRUCTURE: THE FOUR HELIX BUNDLE (HEMERYTHRIN)
File #6 - TERTIARY STRUCTURE: THE BETA BARREL (BACTERIOCHLOROPHYLL PROTEIN)
File #7 - TERTIARY STRUCTURE: A MEMBRANE SPANNING BETA-BARREL (PORIN)
File #8 - MIXED TERTIARY STRUCTURE MOTIFS: THE ZINC FINGER
File #9 - MIXED TERTIARY STRUCTURE MOTIFS: THE ALPHA/BETA BARREL (A COMMON MOTIF)
Ribbon diagram of chicken TIM showing the ligand bound at the C-terminal end of the beta strands
File #10 - MIXED TERTIARY STRUCTURE MOTIF: THE ALPHA/BETA FOLD OF IMPORTANT SIGNALING PROTEINS IN THE HUMAN BODY (Ras PROTEIN)
File #11 - QUATERNARY STRUCTURE: THE COILED-COIL (LEUCINE ZIPPER)
File #12 - QUATERNARY STRUCTURE: ASSOCIATION OF TWO IDENTICAL CHAINS (HIV PROTEASE)
File #13 - QUATERNARY STRUCTURE: ASSOCIATION OF INEQUIVALENT SUBUNITS AND EVOLUTIONARY CONSERVATION (HEMOGLOBIN)
File #14 - QUATERNARY STRUCTURE: ASSOCIATION OF THREE INEQUIVALENT SUBUNITS (PHOTOREACTION CENTER PROTEIN)
File #16 - THE DISULFIDE BRIDGE: STRUCTURAL STABILIZATION OF PROTEINS
File #17 - PROTEIN-DNA INTERACTIONS: LAMBDA REPRESSOR
File #18 - PROTEIN-DNA INTERACTIONS: A ZINC FINGER PROTEIN