The Biofluid Mechanics Laboratory (PI: Gaver) at Tulane University studies the interrelationships between fluid mechanical and physicochemical phenomena and the associated biological behavior of physiological systems. The main thrust of this research involves investigations of the pulmonary system, with the goal of developing improved therapies for pulmonary disease ARDS and the prevention of ventilator-induced lung injury (VILI). In addition, we investigate the design of optimized microfluidiic devices for biosensor technology. These integrated studies bring together basic and applied scientists (including computational scientists), device developers and physicians to study problems of high clinical importance.

Cell Experiments

  • Biological investigations in tissue engineered constructs to study ventilation-associated responses of sensitive pulmonary airway and alveolar epithelial cells.

Bench-top Experiments

  • Experimental investigations using micro-fluidic analogs of pulmonary airways.
  • High resolution visualization technology (micro-PIV) used for interrogating flow fields and elucidating transport phenomena.

Computational Simulations

  • Computational studies that simulate fluid-structure interactions and transport interactions in order to quantify mechanical stress fields of biological significance and predict transport processes that may reduce deleterious mechanical stresses.